SCHEMBL17727882

SCHEMBL17727882

C[C@H]1O[C@H](OC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@@H]32)[C@@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 0.67

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 6/20 0.67
▸ MEN1 O00255 1/20 0.59
▸ ABL1 P00519 1/20 0.59
▸ LMNA P02545 1/20 0.59
▸ PKM P14618 1/20 0.59
▸ IDE P14735 1/20 0.59
▸ MAPK1 P28482 1/20 0.59
▸ KMT2A Q03164 1/20 0.59
▸ RIN1 Q13671 1/20 0.59
▸ L3MBTL1 Q9Y468 1/20 0.59
▸ HLCS P50747 6/20 0.53
▸ HPSE Q9Y251 2/20 0.46
▸ FGF1 P05230 1/20 0.46
▸ FGF2 P09038 1/20 0.46
▸ VEGFA P15692 1/20 0.46
▸ CA12 O43570 4/20 0.45
▸ CA1 P00915 4/20 0.45
▸ CA2 P00918 4/20 0.45
▸ CA9 Q16790 4/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27849533 0.83 TDP1 (0.56) TDP1MEN1ABL1LMNAPKM
SCHEMBL22830876 0.83 TDP1 (0.55) TDP1MEN1ABL1LMNAPKM
SCHEMBL22290232 0.81 TDP1 (0.82) TDP1MEN1ABL1LMNAPKM
SCHEMBL27832339 0.81 TDP1 (0.77) TDP1MEN1ABL1LMNAPKM
SCHEMBL19170150 0.81 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
SCHEMBL21488759 0.81 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
SCHEMBL10047701 0.81 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
SCHEMBL565879 0.81 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
SCHEMBL10047674 0.81 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM
SCHEMBL20844951 0.81 TDP1 (1.00) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10413588-B2 Probiotic function of human intelectin WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2019-09-17 — — US disclosed
US-10082506-B2 Microbial glycans as a target of human intelectin WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2018-09-25 — — US disclosed
US-20170136088-A1 PROBIOTIC FUNCTION OF HUMAN INTELECTIN NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-05-18 — — US disclosed
US-20160131649-A1 MICROBIAL GLYCANS AS A TARGET OF HUMAN INTELECTIN NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-05-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10082506-B2 Microbial glycans as a target of human intelectin HINT1, DERL1, ENGASE TDP1 2856/4885MEN1 1505/4885ABL1 3257/4885
US-20160131649-A1 MICROBIAL GLYCANS AS A TARGET OF HUMAN INTELECTIN HINT1, DERL1, ENGASE TDP1 2856/4885MEN1 1505/4885ABL1 3257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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