Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19087185 | 0.84 | REN (0.42) | RENALDH1A1SMN1; SMN2 | |
| SCHEMBL17721709 | 0.82 | REN (0.37) | RENALDH1A1SMN1; SMN2 | |
| SCHEMBL17261387 | 0.81 | REN (0.48) | REN | |
| SCHEMBL19087210 | 0.80 | REN (0.39) | REN | |
| SCHEMBL20059002 | 0.79 | REN (0.42) | REN | |
| SCHEMBL17721710 | 0.78 | PPARA (0.38) | RENPPARGPPARDPPARAALDH1A1 | |
| SCHEMBL19087208 | 0.78 | REN (0.36) | RENPPARGPPARDPPARAALDH1A1 | |
| SCHEMBL29840524 | 0.77 | REN (0.39) | RENALDH1A1 | |
| SCHEMBL16930095 | 0.77 | REN (0.39) | RENALDH1A1 | |
| SCHEMBL17709276 | 0.77 | LMNA (0.37) | RENPPARGPPARDPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215504-A1 | NOVEL 6,7-DIHYDROBENZO[A]QUINOLIZIN-2-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2017-09-13 | — | — | EP | disclosed |
| WO-2016071215-A1 | NOVEL 6,7-DIHYDROBENZO[A]QUINOLIZIN-2-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2016-05-12 | — | — | WO | disclosed |