Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16981124 | 0.91 | REN (0.37) | RENSMN1; SMN2GLAPPARGPPARD | |
| SCHEMBL19087153 | 0.88 | REN (0.43) | REN | |
| SCHEMBL17721709 | 0.85 | REN (0.37) | RENSMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL17266020 | 0.81 | REN (0.35) | RENSMN1; SMN2GLAPPARGPPARD | |
| SCHEMBL29840524 | 0.80 | REN (0.39) | RENMAPK1LMNAHTTMAPT | |
| SCHEMBL16930095 | 0.80 | REN (0.39) | RENMAPK1LMNAHTTMAPT | |
| SCHEMBL17732271 | 0.78 | REN (0.40) | RENSMN1; SMN2PPARGPPARDPPARA | |
| SCHEMBL19087125 | 0.77 | SIGMAR1 (0.44) | REN | |
| SCHEMBL19087186 | 0.76 | ALDH1A1 (0.37) | RENSMN1; SMN2PPARGPPARDPPARA | |
| SCHEMBL19087185 | 0.75 | REN (0.42) | RENSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114812-A1 | COMBINATION THERAPY OF AN HBSAG INHIBITOR AND AN INTERFERON | F. HOFFMANN-LA ROCHE AG (CH) | 2017-07-06 | — | — | WO | disclosed |