Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | TEK | Q02763 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.42 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28771093 | 0.76 | MET (0.54) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL8145365 | 0.75 | HTR1A (0.61) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL25620343 | 0.71 | MET (0.39) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL29205334 | 0.69 | HTR1A (0.70) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL13443841 | 0.69 | HTR1A (0.57) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL19204448 | 0.68 | PDGFRA (0.48) | METKDRAURKATEKAURKB | |
| SCHEMBL2608925 | 0.68 | HTR1A (0.54) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL14540594 | 0.68 | KDR (0.57) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL3839146 | 0.68 | TLR8 (0.60) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL198210 | 0.68 | KDR (0.54) | HTR1AADRA1DADRA1AADRA1BFERMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408300-B1 | AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE | SUNSHINE LAKE PHARMA CO LTD (CN) | 2016-05-11 | — | — | EP | disclosed |