Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22536973 | 0.87 | TNF (0.46) | SMN1; SMN2ALDH1A1HTTKDM4EMAPT | |
| SCHEMBL22536978 | 0.80 | MAPT (0.38) | ALDH1A1LMNAHPGDKDM4EMAPT | |
| SCHEMBL22536986 | 0.76 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1LMNAHTTKDM4E | |
| SCHEMBL17737476 | 0.73 | ALOX12 (0.62) | ALDH1A1LMNAHTTKDM4EMAPT | |
| SCHEMBL21783687 | 0.68 | TNF (0.49) | SMN1; SMN2ALDH1A1LMNAKDM4EMAPT | |
| SCHEMBL2481375 | 0.68 | TNF (0.49) | SMN1; SMN2ALDH1A1LMNAHTTKDM4E | |
| SCHEMBL619607 | 0.65 | CYP1A2 (0.54) | LMNAHTTKDM4ETNFALOX12 | |
| SCHEMBL13905716 | 0.65 | FADS1 (0.41) | SMN1; SMN2ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL2622216 | 0.64 | LATS1 (0.46) | SMN1; SMN2ALDH1A1LMNAMAPTTRPV1 | |
| Hydrochloric Acid SCHEMBL11739254 | 0.64 | CYP1A2 (0.52) | LMNAHTTKDM4ETNFALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016071283-A1 | INHIBITORS OF TRYPTOPHAN-2,3-DIOXYGENASE OR INDOLEAMINE-2,3-DIOXYGENASE | IOMET PHARMA LTD (GB) | 2016-05-12 | — | — | WO | disclosed |