SCHEMBL1774347

SCHEMBL1774347

Fc1cccc(-c2ccc(Br)cc2)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.63
ESR2 Q92731 1/20 0.63
ALDH1A1 P00352 1/20 0.54
MAPK1 P28482 1/20 0.54
CYP11B2 P19099 2/20 0.50
CYP17A1 P05093 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP11B1 P15538 1/20 0.50
PTPN1 P18031 1/20 0.47
AMY1A P0DUB6 1/20 0.47
GABRP O00591 1/20 0.45
GABRD O14764 1/20 0.45
GABRA1 P14867 1/20 0.45
GABRB1 P18505 1/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
GABRA2 P47869 1/20 0.45
GABRB2 P47870 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19929774 0.89 TAAR1 (0.52) TAAR1ESR2ALDH1A1MAPK1CYP11B2
SCHEMBL9292507 0.84 TAAR1 (0.54) TAAR1ESR2CYP11B2CYP17A1CYP3A4
SCHEMBL15605009 0.83 TAAR1 (0.71) TAAR1ESR2ALDH1A1CYP11B2CYP17A1
SCHEMBL777750 0.83 TAAR1 (0.71) TAAR1ESR2CYP11B2CYP17A1CYP3A4
SCHEMBL12619988 0.83 ALDH1A1 (0.68) ALDH1A1MAPK1CYP11B2CYP3A4CYP11B1
SCHEMBL3946608 0.83 ALDH1A1 (0.68) ALDH1A1MAPK1CYP11B2CYP3A4CYP11B1
SCHEMBL851174 0.83 TAAR1 (0.53) TAAR1ESR2CYP11B2CYP17A1CYP3A4
SCHEMBL198702 0.83 TAAR1 (0.68) TAAR1ESR2CYP11B2CYP17A1CYP3A4
SCHEMBL7796200 0.81 TAAR1 (0.50) TAAR1ESR2ALDH1A1MAPK1CYP11B2
Biphenyl SCHEMBL25183774 0.80 TAAR1 (0.67) TAAR1ESR2ALDH1A1CYP11B2CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110790641-B Method for producing compound having oxydifluoromethylene skeleton 大金工业株式会社 2023-02-28 CN disclosed
US-11588115-B2 Nitrogen-containing compound, organic electroluminescent device and electronic apparatus SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD. (CN) 2023-02-21 US disclosed
CN-113234036-A NMDA receptor antagonists and uses thereof 中国科学院上海有机化学研究所 2021-08-10 CN disclosed
WO-2021135181-A1 NITROGEN-CONTAINING COMPOUND, ORGANIC ELECTROLUMINESCENT DEVICE AND ELECTRONIC DEVICE 陕西莱特光电材料股份有限公司 2021-07-08 WO disclosed
CN-106132915-B Method for producing compound having oxydifluoromethylene skeleton 大金工业株式会社 2020-03-31 CN disclosed
CN-110790641-A Method for producing compound having oxydifluoromethylene skeleton 大金工业株式会社 2020-02-14 CN disclosed
EP-2842974-B1 COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC CORP (JP) 2019-03-13 EP disclosed
EP-3199558-A1 COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC Corporation (JP) 2017-08-02 EP disclosed
EP-3121160-A1 METHOD FOR PRODUCING COMPOUND HAVING OXYDIFLUOROMETHYLENE SKELETON Daikin Industries, Ltd. (JP) 2017-01-25 EP disclosed
EP-2842974-A1 COMPOUND HAVING FOUR POLYMERIZABLE GROUPS, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT JNC Corporation (JP) 2015-03-04 EP disclosed
CN-102256969-A Compounds that modulate intracellular calcium CALCIMEDICA INC 2011-11-23 CN disclosed
US-20110112103-A1 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-05-12 US disclosed
EP-0637623-B1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK & CHEMICALS (JP) 2001-10-04 EP disclosed
EP-0893424-A1 ALPHA,ALPHA-DIFLUOROBENZYL ETHER DERIVATIVES, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORPORATION (JP) 1999-01-27 EP disclosed
US-5536443-A DUTERIUM CONTAINING COMPOUNDS FOOR ELECTROOPTICAL APPARATUS DAINIPPON INK & CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5474707-A Electrooptic display DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-12-12 US disclosed
EP-0637623-A1 Cyclic hydrocarbon derivative and liquid crystal composition containing the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1995-02-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11588115-B2 Nitrogen-containing compound, organic electroluminescent device and electronic apparatus NCL, NCLN, NNMT TAAR1 2366/4885ESR2 901/4885ALDH1A1 3230/4885
US-20110112103-A1 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND EPOR, CBR1, CBR3 TAAR1 1789/4885ESR2 93/4885ALDH1A1 1179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.