Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 3/20 | 0.47 |
| ▸ | TEK | Q02763 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 6/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773533 | 0.82 | SMYD3 (0.55) | KDRSMYD3AURKAMETTEK | |
| SCHEMBL2747078 | 0.79 | DRD4 (0.67) | DRD4KDM4EALDH1A1HPGDDPP4 | |
| SCHEMBL12801478 | 0.76 | PTPN1 (0.62) | KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL6121152 | 0.76 | NPC1 (0.57) | KDRAURKAMETTEKLCK | |
| SCHEMBL14756885 | 0.75 | KDM4E (0.57) | KDRAURKAMETTEKAURKB | |
| SCHEMBL4043511 | 0.74 | HPGD (0.64) | SMYD3P2RX7ALDH1A1HPGDKMT2A | |
| SCHEMBL15940756 | 0.74 | HPGD (0.55) | SMYD3P2RX7ALDH1A1HPGDKMT2A | |
| SCHEMBL29953310 | 0.74 | HPGD (0.52) | P2RX7KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL29955977 | 0.74 | HPGD (0.55) | SMYD3P2RX7ALDH1A1HPGDKMT2A | |
| SCHEMBL457248 | 0.74 | NPC1 (0.50) | P2RX7HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108631-B | 6-amino-7-bicyclic-7-deaza-purine derivatives as protein kinase inhibitors | 内尔维阿诺医学科学有限公司 | 2020-06-16 | — | — | CN | disclosed |
| US-10221181-B2 | 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-03-05 | — | — | US | disclosed |
| US-10221181-B2 | 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-03-05 | — | — | US | disclosed |
| US-20170327506-A1 | 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | NERVIANO MEICAL SCIENCES S.r.l. (IT) | 2017-11-16 | — | — | US | disclosed |
| US-20170327506-A1 | 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | NERVIANO MEICAL SCIENCES S.r.l. (IT) | 2017-11-16 | — | — | US | disclosed |
| EP-3218378-A1 | 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016075224-A1 | 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-05-19 | — | — | WO | disclosed |
| WO-2016075224-A1 | 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327506-A1 | 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | DCK, RET, ADK | KDR 553/4885SMYD3 3201/4885AURKA 558/4885 |
| US-10221181-B2 | 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors | DCK, RET, PRKCA | KDR 436/4885SMYD3 3655/4885AURKA 712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.