Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15001426 | 0.76 | MAPT (0.39) | MAPTSMN1; SMN2ALDH1A1HTTHRH3 | |
| SCHEMBL17749721 | 0.76 | L3MBTL1 (0.43) | PDE4BALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL29947770 | 0.75 | PDE4B (0.44) | MAPTSMN1; SMN2PDE4BALDH1A1HTT | |
| SCHEMBL26739679 | 0.75 | MAPT (0.43) | MAPTSMN1; SMN2PDE4BALDH1A1HTT | |
| SCHEMBL585841 | 0.74 | NCF1 (0.54) | SMN1; SMN2PDE4BALDH1A1HTTKDM4E | |
| SCHEMBL146568 | 0.73 | HRH3 (0.56) | MAPTSMN1; SMN2ALDH1A1HTTHPGD | |
| SCHEMBL552986 | 0.73 | PRMT6 (0.40) | MAPTSMN1; SMN2ALDH1A1HTTHRH3 | |
| Hydrochloric Acid SCHEMBL15845597 | 0.73 | NCF1 (0.52) | SMN1; SMN2PDE4BALDH1A1HTTKDM4E | |
| SCHEMBL29739553 | 0.73 | ALDH1A1 (0.53) | MAPTSMN1; SMN2PDE4BALDH1A1HTT | |
| SCHEMBL29177423 | 0.73 | ALDH1A1 (0.53) | MAPTSMN1; SMN2PDE4BALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | Genentech, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |