Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1776105 | 0.99 | HTR2C (0.40) | HTR2CHTR6ALDH1A1USP2TSHR | |
| SCHEMBL1776423 | 0.89 | HTR6 (0.45) | HTR2CHTR6ALDH1A1USP2TSHR | |
| SCHEMBL1774379 | 0.86 | HTR2C (0.39) | HTR2CHTR6USP2TSHRHSD17B10 | |
| SCHEMBL1775970 | 0.85 | HSD11B1 (0.41) | HTR2CHTR6USP2TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL1774530 | 0.84 | HSD11B1 (0.41) | HTR2CHTR6USP2TSHRHSD17B10 | |
| SCHEMBL6382957 | 0.83 | HTR6 (0.47) | HTR2CHTR6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5012454 | 0.81 | HTR2C (0.39) | HTR2CHTR6ALDH1A1USP2TSHR | |
| SCHEMBL1775382 | 0.81 | HTR6 (0.45) | HTR2CHTR6ALDH1A1USP2TSHR | |
| SCHEMBL5015941 | 0.77 | HTR2C (0.53) | HTR2CHTR6HTR1A | |
| SCHEMBL1776417 | 0.75 | HTR6 (0.48) | HTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |