Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776423 | 0.87 | HTR6 (0.45) | HTR2CHTR6USP2TSHRHSD17B10 | |
| SCHEMBL1775389 | 0.86 | HTR2C (0.40) | HTR2CHTR6USP2TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL1776105 | 0.85 | HTR2C (0.40) | HTR2CHTR6USP2TSHRHSD17B10 | |
| SCHEMBL1775970 | 0.83 | HSD11B1 (0.41) | HTR2CHTR6USP2TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL1774530 | 0.83 | HSD11B1 (0.41) | HTR2CHTR6USP2TSHRHSD17B10 | |
| SCHEMBL1777105 | 0.81 | HTR2C (0.45) | HTR2CHTTHTR6NCF1 | |
| Hydrochloric Acid SCHEMBL1774728 | 0.81 | HTR2C (0.44) | HTR2CHTTHTR6NCF1 | |
| SCHEMBL1775766 | 0.80 | HTR2C (0.40) | HTR2CHTTHTR6NCF1USP2 | |
| SCHEMBL6385040 | 0.80 | HTR6 (0.47) | HTR2CHTTHTR6NCF1 | |
| SCHEMBL1775382 | 0.79 | HTR6 (0.45) | HTR2CHTR6USP2TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |