Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.32 |
| ▸ | HTR1B | P28222 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1774530 | 0.99 | HSD11B1 (0.41) | HSD11B1HTR2CUSP2TSHRHSD17B10 | |
| SCHEMBL1776423 | 0.86 | HTR6 (0.45) | HTR2CUSP2TSHRHSD17B10HTR6 | |
| SCHEMBL1775389 | 0.85 | HTR2C (0.40) | HTR2CUSP2TSHRHSD17B10CLK4 | |
| Hydrochloric Acid SCHEMBL1776105 | 0.84 | HTR2C (0.40) | HTR2CUSP2TSHRHSD17B10CLK4 | |
| Hydrochloric Acid SCHEMBL1775164 | 0.84 | HTR2C (0.37) | HTR2CUSP2TSHRHSD17B10CLK4 | |
| SCHEMBL6386118 | 0.84 | HTR6 (0.46) | HTR2CHTR6KDM4ECYP1A2CYP3A4 | |
| SCHEMBL1774379 | 0.83 | HTR2C (0.39) | HTR2CUSP2TSHRHSD17B10CLK4 | |
| SCHEMBL1775382 | 0.80 | HTR6 (0.45) | HSD11B1HTR2CUSP2TSHRHSD17B10 | |
| SCHEMBL5015941 | 0.75 | HTR2C (0.53) | HTR2CHTR6HTR1ADRD2HTR7 | |
| SCHEMBL1775723 | 0.73 | HTR6 (0.45) | HTR2CHTR6HTR1AHTR7HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |