Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 7/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.41 |
| ▸ | PARP1 | P09874 | 6/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.39 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.39 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858049 | 0.92 | TSHR (0.60) | TSHRCYP19A1TNKSTNKS2PARP1 | |
| SCHEMBL18802754 | 0.89 | KIF11 (0.44) | TSHRTNKSTNKS2PARP1ADORA3 | |
| SCHEMBL547767 | 0.89 | KIF11 (0.44) | TSHRTNKSTNKS2PARP1ADORA3 | |
| SCHEMBL17752217 | 0.82 | KIF11 (0.56) | TSHRTDP1NPC1RAB9AKIF11 | |
| SCHEMBL13694443 | 0.82 | KIF11 (0.44) | TSHRTNKSTNKS2PARP1TDP1 | |
| SCHEMBL11623508 | 0.81 | TSHR (0.48) | TSHRCYP19A1TNKSTNKS2PARP1 | |
| SCHEMBL196799 | 0.81 | MEN1 (0.48) | TSHRTNKSTNKS2PARP1TDP1 | |
| SCHEMBL10781469 | 0.80 | ESR1 (0.56) | TSHRSLC6A3KIF11ABL1 | |
| SCHEMBL429422 | 0.80 | CYP2C9 (0.56) | TNKSTNKS2PARP1MAPTKIF11 | |
| SCHEMBL4506291 | 0.80 | CYP2C9 (0.56) | TNKSTNKS2PARP1MAPTKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170143649-A1 | IMMUNOREGULATORY AGENTS | FLEXUS BIOSCIENCES INC (US) | 2017-05-25 | — | — | US | disclosed |
| US-9598422-B2 | Immunoregulatory agents | FLEXUS BIOSCIENCES, INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20160137653-A1 | IMMUNOREGULATORY AGENTS | FLEXUS BIOSCIENCES, INC. | 2016-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137653-A1 | IMMUNOREGULATORY AGENTS | IDO1, IDO2, INMT | TSHR 2899/4885CYP19A1 271/4885TNKS 1083/4885 |
| US-20170143649-A1 | IMMUNOREGULATORY AGENTS | IDO1, IDO2, INMT | TSHR 2899/4885CYP19A1 271/4885TNKS 1083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.