Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12650618 | 0.89 | ELANE (0.41) | SMN1; SMN2ALDH1A1ADRB2POLBTSHR | |
| SCHEMBL21643553 | 0.87 | FKBP1A (0.55) | FKBP1A | |
| SCHEMBL2767965 | 0.87 | FKBP1A (0.55) | FKBP1A | |
| SCHEMBL21643480 | 0.85 | STAT3 (0.46) | STAT3SMN1; SMN2ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL21643436 | 0.85 | FKBP1A (0.48) | STAT3SMN1; SMN2ALDH1A1KDM4EFKBP1A | |
| SCHEMBL21643483 | 0.85 | STAT3 (0.46) | STAT3SMN1; SMN2ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL21643438 | 0.85 | FKBP1A (0.48) | STAT3SMN1; SMN2ALDH1A1KDM4EFKBP1A | |
| SCHEMBL21643379 | 0.84 | STAT3 (0.47) | STAT3SMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL21643376 | 0.84 | STAT3 (0.47) | STAT3SMN1; SMN2ALDH1A1KDM4ELMNA | |
| SCHEMBL21643523 | 0.83 | STAT3 (0.46) | STAT3SMN1; SMN2LMNAPKMFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943775-B2 | to detect amyloid deposits prior to aggregation into plaques; labeled bifunctional compound binds to target protein and to chaperone protein; Alzheimer's; 1-[4-(carboxymethoxy)phenyl]-3-(3,4-dimethoxy-phenyl)-1-propanyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate isomers bind differently | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943775-B2 | to detect amyloid deposits prior to aggregation into plaques; labeled bifunctional compound binds to target protein and to chaperone protein; Alzheimer's; 1-[4-(carboxymethoxy)phenyl]-3-(3,4-dimethoxy-phenyl)-1-propanyl-1-(3,3-dimethyl-1,2-dioxopentyl)-2-piperidinecarboxylate isomers bind differently | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-05-17 | — | — | US | disclosed |
| US-20080085238-A1 | Small Molecules for Imaging Protein-Protein Interactions | The Government of the United States of America as represented (US) | 2008-04-10 | — | — | US | disclosed |
| US-20080085238-A1 | Small Molecules for Imaging Protein-Protein Interactions | The Government of the United States of America as represented (US) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085238-A1 | Small Molecules for Imaging Protein-Protein Interactions | HSPBP1, HSPA2, HSPA8 | STAT3 4277/4885SMN1; SMN2 2815/4885ALDH1A1 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.