Boldine

Boldine

SCHEMBL177549

COc1cc2c(cc1O)CC1c3c(cc(O)c(OC)c3-2)CCN1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 1.00
▸ HSD17B10 Q99714 7/20 1.00
▸ HPGD P15428 7/20 1.00
▸ KDM4E B2RXH2 7/20 1.00
▸ MAPT P10636 6/20 1.00
▸ CYP3A4 P08684 5/20 1.00
▸ CYP2D6 P10635 5/20 1.00
▸ DRD1 P21728 5/20 1.00
▸ DRD2 P14416 4/20 1.00
▸ CYP2C9 P11712 3/20 1.00
▸ MEN1 O00255 3/20 1.00
▸ KMT2A Q03164 3/20 1.00
▸ CYP1A2 P05177 2/20 1.00
▸ HIF1A Q16665 2/20 1.00
▸ CHRNB2 P17787 2/20 1.00
▸ CHRNA7 P36544 2/20 1.00
▸ CHRNA4 P43681 2/20 1.00
▸ LMNA P02545 1/20 1.00
▸ CSNK2A2 P19784 1/20 1.00
▸ CSNK2B P67870 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Boldine SCHEMBL29973042 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EMAPT
Boldine SCHEMBL7387149 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EMAPT
Boldine SCHEMBL13459203 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EMAPT
Boldine SCHEMBL177550 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EMAPT
Boldine SCHEMBL30184400 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EMAPT
Boldine SCHEMBL3060583 0.99 ALDH1A1 (0.98) ALDH1A1HSD17B10HPGDKDM4EMAPT
Predicentrine SCHEMBL25844649 0.95 ALDH1A1 (0.91) ALDH1A1HSD17B10HPGDKDM4EMAPT
Predicentrine SCHEMBL4410538 0.95 ALDH1A1 (0.91) ALDH1A1HSD17B10HPGDKDM4EMAPT
Boldine SCHEMBL420488 0.94 ALDH1A1 (0.89) ALDH1A1HSD17B10HPGDKDM4EMAPT
SCHEMBL30475142 0.94 HTR7 (1.00) ALDH1A1HSD17B10HPGDKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 905 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250161243-A1 MEF2 TRANSCRIPTIONAL ACTIVATORS TO TREAT NEUROLOGIC CONDITIONS THE SCRIPPS RESEARCH INSTITUTE 2025-05-22 — — US claimed
US-20250057962-A1 PROCESSABLE COMPOSITIONS AND USE FOR THE SAME RIPPLE THERAPEUTICS CORPORATION (CA) 2025-02-20 — — US claimed
CN-118703454-A Cytochrome P450 enzyme from stephania tetrandra and application thereof in biosynthesis of aporphine alkaloid compound 中国中医科学院中药研究所 2024-09-27 — — CN claimed
EP-4426712-A1 PROCESSABLE COMPOSITIONS AND USE FOR THE SAME Ripple Therapeutics Corporation (CA) 2024-09-11 — — EP claimed
CN-118547022-A Preparation method of aporphine alkaloid compound and related catalytic enzyme and application thereof 中国中医科学院中药研究所 2024-08-27 — — CN claimed
US-20240261252-A1 Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses. HELDRETH JR DAVID ALAN (US) 2024-08-08 — — US claimed
US-20230279170-A1 CHIRAL-SUBSTITUTED POLY-N-VINYLPYRROLIDINONES AND COMPLEXES WITH BIMETALLIC NANOCLUSTERS AND USES THEREOF KANSAS STATE UNIVERSITY RESEARCH FOUNDATION 2023-09-07 — — US claimed
CN-113801843-B Method for enhancing human urine-derived stem cell stem property 北京中医药大学 2023-06-30 — — CN claimed
WO-2023079362-A1 PROCESSABLE COMPOSITIONS AND USE FOR THE SAME RIPPLE THERAPEUTICS CORPORATION (CA) 2023-05-11 — — WO claimed
CN-115916142-A Coupled terpene conjugates 埃里格实验室公司 2023-04-04 — — CN claimed
EP-1117376-A1 USE OF A BOLDO EXTRACT IN A COSMETIC OR DERMATOLOGICAL PRODUCT LABORATOIRES SEROBIOLOGIQUES (FR) 2001-07-25 — — EP claimed
WO-2000059466-A1 COSMETIC COMPOSITION COMPRISING A LIPID SKELETONEMA EXTRACT LVMH RECHERCHE (FR) 2000-10-12 — — WO claimed
WO-2000019973-A1 USE OF A BOLDO EXTRACT IN A COSMETIC OR DERMATOLOGICAL PRODUCT COGNIS FRANCE, S.A. (FR) 2000-04-13 — — WO claimed
EP-0592622-B1 EXTENSION OF EDIBLE OIL LIFETIME USING ACTIVATED CARBONS CALGON CARBON CORP (US) 1997-06-25 — — EP claimed
CN-1103863-A Secoaporphine compound, its preparation method and medicinal composition containing said compound SU MINGJIA (CN) 1995-06-21 — — CN claimed
US-5348755-A Extension of edible oil lifetime using activated carbons CALGON CARBON CORPORATION (US) 1994-09-20 — — US claimed
EP-0592622-A4 — — 1994-08-03 — — EP claimed
EP-0592622-A1 EXTENSION OF EDIBLE OIL LIFETIME USING ACTIVATED CARBONS. CALGON CARBON CORP (US) 1994-04-20 — — EP claimed
WO-1993017567-A1 EXTENSION OF EDIBLE OIL LIFETIME USING ACTIVATED CARBONS CALGON CARBON CORPORATION (US) 1993-09-16 — — WO claimed
US-4185119-A Antiallergic methods FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1980-01-22 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250057962-A1 PROCESSABLE COMPOSITIONS AND USE FOR THE SAME CCND2, CCND1, C9 ALDH1A1 2326/4885HSD17B10 878/4885HPGD 308/4885
US-20250161243-A1 MEF2 TRANSCRIPTIONAL ACTIVATORS TO TREAT NEUROLOGIC CONDITIONS MEF2D, TEAD2, TEAD1 ALDH1A1 2530/4885HSD17B10 1871/4885HPGD 4377/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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