Boldine

Boldine

SCHEMBL420488

CC(=O)C(C)=O.COc1cc2c(cc1O)CC1c3c(cc(O)c(OC)c3-2)CCN1C

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.89
HSD17B10 Q99714 7/20 0.89
HPGD P15428 7/20 0.89
KDM4E B2RXH2 7/20 0.89
DRD1 P21728 6/20 0.89
MAPT P10636 6/20 0.89
CYP3A4 P08684 5/20 0.89
CYP2D6 P10635 5/20 0.89
DRD2 P14416 5/20 0.89
CYP2C9 P11712 3/20 0.89
MEN1 O00255 3/20 0.89
KMT2A Q03164 3/20 0.89
CYP1A2 P05177 2/20 0.89
HIF1A Q16665 2/20 0.89
CHRNB2 P17787 2/20 0.89
CHRNA7 P36544 2/20 0.89
CHRNA4 P43681 2/20 0.89
LMNA P02545 1/20 0.89
CSNK2A2 P19784 1/20 0.89
CSNK2B P67870 1/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Boldine SCHEMBL7387149 0.94 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EDRD1
Boldine SCHEMBL177549 0.94 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EDRD1
Boldine SCHEMBL13459203 0.94 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EDRD1
Boldine SCHEMBL29973042 0.94 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EDRD1
Boldine SCHEMBL177550 0.94 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EDRD1
Boldine SCHEMBL30184400 0.94 ALDH1A1 (1.00) ALDH1A1HSD17B10HPGDKDM4EDRD1
Boldine SCHEMBL3060583 0.93 ALDH1A1 (0.98) ALDH1A1HSD17B10HPGDKDM4EDRD1
Predicentrine SCHEMBL4410538 0.90 ALDH1A1 (0.91) ALDH1A1HSD17B10HPGDKDM4EDRD1
Predicentrine SCHEMBL25844649 0.90 ALDH1A1 (0.91) ALDH1A1HSD17B10HPGDKDM4EDRD1
SCHEMBL4854015 0.89 HTR7 (1.00) ALDH1A1HSD17B10HPGDKDM4EDRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119548428-B Composition for resisting heat stimulus and UV stimulus, application and cosmetic 广东省禾基生物科技有限公司 2025-06-10 CN claimed
CN-114796088-B Freckle removing composition, cosmetic and preparation method thereof 佐登妮丝(广州)美容化妆品有限公司 2023-04-14 CN claimed
CN-115024985-A Stick-shaped solid cosmetic 彭氏(惠州)实业发展有限公司 2022-09-09 CN claimed
CN-114796088-A Freckle removing composition, cosmetic and preparation method thereof 佐登妮丝(广州)美容化妆品有限公司 2022-07-29 CN claimed
CN-114712288-A Whitening and moisturizing essence cream 彭氏(惠州)实业发展有限公司 2022-07-08 CN claimed
WO-2021250519-A2 COMPOSITIONS FOR TOPICAL TREATMENT OF ACQUIRED MELANOSIS OF THE SKIN PROFESSIONAL DIETETICS S.P.A. (IT) 2021-12-16 WO claimed
EP-3922236-A1 COMPOSITIONS FOR TOPICAL TREATMENT OF ACQUIRED MELANOSIS OF THE SKIN Professional Dietetics S.p.A. (IT) 2021-12-15 EP claimed
CN-113248364-A Method for solubilizing azelaic acid 无锡元旭生物技术有限公司 2021-08-13 CN claimed
CN-110946796-A Whitening composition containing endothelin antagonist and preparation method and application thereof 苏州绿叶日用品有限公司 2020-04-03 CN claimed
CN-110302071-A Blue light protection cosmetic composition and preparation method thereof and the cosmetics for including the composition 苏州绿叶日用品有限公司 2019-10-08 CN claimed
US-20090258093-A1 Use of a brassocattleya marcella koss orchid extract as an active agent to prevent or delay the appearance of signs of cutaneous aging L.V.M.H. RECHERCHE 2009-10-15 US claimed
US-20090232758-A1 Brassocattleya marcella koss orchid extract and use thereof as skin depigmentation agent L V M H RECHERCHE 2009-09-17 US claimed
CN-101496774-A Cosmetic composition comprising ascorbic acid 2-glucoside and ergothioneine LVMH RECH (FR) 2009-08-05 CN claimed
US-20090117061-A1 SKIN CARE PRODUCTS CONTAINING MULTIPLE ENHANCERS SHISEIDO AMERICAS CORPORATION 2009-05-07 US claimed
WO-2009046116-A1 SKIN CARE PRODUCTS CONTAINING MULTIPLE ENHANCERS GROSS DENNIS (US) 2009-04-09 WO claimed
US-20090068219-A1 Anti-wrinkle hormone-type cosmetic composition 3LAB, INC. (US) 2009-03-12 US claimed
EP-1680067-B1 COMPOSITION FOR THE COSMETIC TREATMENT OF AGE-RELATED DERMATOLOGICAL SYMPTOMS CORTEX TECHNOLOGY APS (DK) 2009-02-25 EP claimed
US-20070292527-A1 Composition for the cosmetic treatment of age-related dermatological symptoms DAIMLERCHRYSLER AG (DE) 2007-12-20 US claimed
EP-1680067-A2 COMPOSITION FOR THE COSMETIC TREATMENT OF AGE-RELATED DERMATOLOGICAL SYMPTOMS Cortex Technology Aps (DK) 2006-07-19 EP claimed
WO-2005041854-A2 COMPOSITION FOR THE COSMETIC TREATMENT OF AGE-RELATED DERMATOLOGICAL SYMPTOMS CORTEX TECHNOLOGY APS (DK) 2005-05-12 WO claimed