Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL3093521 | 0.94 | — | — | |
| Propanol SCHEMBL11328156 | 0.92 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4ESMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL27635431 | 0.92 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4ESMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL218583 | 0.91 | ALDH1A1 (0.53) | ALDH1A1TSHR | |
| Alcohol SCHEMBL7807841 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TSHR | |
| Tetrahydrofuran SCHEMBL30232 | 0.88 | — | — | |
| Tetrahydrofuran SCHEMBL8412489 | 0.88 | ALDH1A1 (0.57) | ALDH1A1TSHRKDM4E | |
| Tetrahydrofuran SCHEMBL2513702 | 0.86 | ALDH1A1 (0.42) | ALDH1A1KDM4E | |
| Alcohol SCHEMBL4270003 | 0.85 | ALDH1A1 (0.53) | ALDH1A1TSHR | |
| Tetrahydrofuran SCHEMBL241626 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943115-B2 | Hydrotreating catalyst and/or carrier; heat stability; desulfurization and denitrogenation of hydrocarbon oils; prepared using particle growth inhibiter | CHIYODA CORPORATION (JP) | 2011-05-17 | — | — | US | disclosed |
| US-20040238410-A1 | Porous 4 group metal oxide and method for preparation thereof | CHIYODA CORPORATION (JP) | 2004-12-02 | — | — | US | disclosed |