Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL7807841 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRPDK1PDK2PDK3 | |
| Tetrahydrofuran SCHEMBL30232 | 0.97 | — | — | |
| Tetrahydrofuran SCHEMBL8412489 | 0.97 | ALDH1A1 (0.57) | ALDH1A1TSHRTTRPDK1PDK2 | |
| Tetrahydrofuran SCHEMBL28397015 | 0.93 | ALDH1A1 (0.53) | ALDH1A1TSHRTTRPDK1PDK2 | |
| Alcohol SCHEMBL15013700 | 0.93 | — | — | |
| Tetrahydrofuran SCHEMBL4858668 | 0.93 | — | — | |
| Tetrahydrofuran SCHEMBL241626 | 0.93 | — | — | |
| Alcohol SCHEMBL3138912 | 0.93 | ALDH1A1 (0.53) | ALDH1A1TSHRTTRPDK1PDK2 | |
| Alcohol SCHEMBL4270003 | 0.93 | ALDH1A1 (0.53) | ALDH1A1TSHRTTRPDK1PDK2 | |
| Tetrahydrofuran SCHEMBL1775706 | 0.91 | ALDH1A1 (0.44) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116925105-A | Solid salt forms, crystalline forms, and methods of making, compositions, and uses of opioid receptor antagonist conjugates | 上海瀚迈生物医药科技有限公司 | 2023-10-24 | — | — | CN | disclosed |
| WO-2023197934-A1 | SOLID SALT FORM OF OPIOID RECEPTOR ANTAGONIST CONJUGATE, CRYSTAL FORM, PREPARATION METHOD THEREFOR, COMPOSITION, AND USE | 上海瀚迈生物医药科技有限公司 | 2023-10-19 | — | — | WO | disclosed |
| CN-101076528-B | Organic compound, charge transport material, and organic electroluminescent device | MITSUBISHI CHEM CORP | 2012-06-20 | — | — | CN | disclosed |
| US-8088875-B2 | (Meth)acrylate, polymer and resist composition | MITSUBISHI RAYON CO., LTD. (JP) | 2012-01-03 | — | — | US | disclosed |
| US-20080003529-A1 | (Meth)Acrylate, Polymer and Resist Composition | MITSUBISHI RAYON CO., LTD. (JP) | 2008-01-03 | — | — | US | disclosed |
| CN-101076528-A | Organic compound, charge transport material, and organic electroluminescent device | PIONEER ELECTRONIC CORP (JP) | 2007-11-21 | — | — | CN | disclosed |
| US-4645766-A | 1,2-dihydro-2-oxo-3-hydroxymethyl pyridines, compositions and use | THE UPJOHN COMPANY (US) | 1987-02-24 | — | — | US | disclosed |