Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL28397015 | 1.00 | ALDH1A1 (0.53) | — | |
| Alcohol SCHEMBL8347532 | 0.97 | ALDH1A1 (0.50) | — | |
| Tetrahydrofuran SCHEMBL30232 | 0.97 | — | — | |
| Tetrahydrofuran SCHEMBL8412489 | 0.97 | ALDH1A1 (0.57) | — | |
| Alcohol SCHEMBL3138912 | 0.93 | ALDH1A1 (0.53) | — | |
| Tetrahydrofuran SCHEMBL218583 | 0.93 | ALDH1A1 (0.53) | — | |
| Tetrahydrofuran SCHEMBL4858668 | 0.93 | — | — | |
| Alcohol SCHEMBL4270003 | 0.93 | ALDH1A1 (0.53) | — | |
| Alcohol SCHEMBL15013700 | 0.93 | — | — | |
| Alcohol SCHEMBL7807841 | 0.90 | ALDH1A1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117510567-A | Method for preparing high-purity alfaxalone | 长沙启晟合研医药科技有限公司 | 2024-02-06 | — | — | CN | claimed |
| CN-115677668-B | Anserine derivative, and preparation method and application thereof | 东南大学 | 2023-12-05 | — | — | CN | claimed |
| CN-114920908-B | Fluorenone-containing organic conjugated polymer and application thereof in synthesis of alpha-ketoester | 福州大学 | 2023-04-21 | — | — | CN | claimed |
| CN-115677668-A | Anserine derivative and preparation method and application thereof | 东南大学 | 2023-02-03 | — | — | CN | claimed |
| WO-2024144149-A1 | HETEROARYL DERIVATIVE COMPOUND AND USE THEREOF | 보로노이 주식회사 | 2024-07-04 | — | — | WO | disclosed |
| CN-117510567-A | Method for preparing high-purity alfaxalone | 长沙启晟合研医药科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115677668-B | Anserine derivative, and preparation method and application thereof | 东南大学 | 2023-12-05 | — | — | CN | disclosed |
| US-20230382924-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED | 2023-11-30 | — | — | US | disclosed |
| EP-3594211-B1 | ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF | CELGENE CORP (US) | 2023-10-25 | — | — | EP | disclosed |
| EP-4225446-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| CN-114920908-B | Fluorenone-containing organic conjugated polymer and application thereof in synthesis of alpha-ketoester | 福州大学 | 2023-04-21 | — | — | CN | disclosed |
| CN-115677668-A | Anserine derivative and preparation method and application thereof | 东南大学 | 2023-02-03 | — | — | CN | disclosed |
| US-5117109-A | EXCHANGE METHOD OF MOBILE PHASE IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY MASS SPECTROMETRY AND ITS APPARATUS | EISAI CO. LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| CN-1049339-A | Reclaim the method for tetrahydrofuran (THF) from the mixture that contains tetrahydrofuran (THF) and lower alkanols and water | DAVY MCKEE LONDON (GB) | 1991-02-20 | — | — | CN | disclosed |
| US-4952583-A | DIURETIC HYPOTENSIVE AGENTS | ICI AMERICAS INC. (US) | 1990-08-28 | — | — | US | disclosed |
| US-4490527-A | Benzo-fused heterocyclic anti-ulcer agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0010369-B1 | CLAVULANIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1983-07-20 | — | — | EP | disclosed |
| US-4388300-A | OXAPENICILLIN ANTIBIOTICS | BEECHAM GROUP LIMITED (GB) | 1983-06-14 | — | — | US | disclosed |
| US-4349551-A | Penicillin derivatives and compositions containing them | BEECHAM GROUP LIMITED (GB) | 1982-09-14 | — | — | US | disclosed |
| EP-0010369-A1 | Clavulanic acid derivatives, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1980-04-30 | — | — | EP | disclosed |