Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757080 | 0.90 | ACAT2 (0.38) | LMNANPC1RAB9AHTT | |
| SCHEMBL17757117 | 0.89 | ACAT2 (0.37) | KDM4ENPC1GAAMAPTMAPK1 | |
| SCHEMBL17757846 | 0.89 | LMNA (0.39) | LMNAKDM4ENPC1GAAMAPT | |
| SCHEMBL17757089 | 0.89 | ROCK2 (0.33) | LMNA | |
| SCHEMBL17992087 | 0.88 | LMNA (0.33) | LMNA | |
| SCHEMBL17757737 | 0.88 | ACAT2 (0.33) | KDM4ENPC1GAAMAPTMAPK1 | |
| SCHEMBL17757540 | 0.87 | GAA (0.34) | LMNAKDM4ENPC1GAAMAPT | |
| SCHEMBL19523219 | 0.87 | PTPN1 (0.45) | LMNAKDM4ENPC1GAAMAPT | |
| SCHEMBL17758070 | 0.87 | KDM4E (0.36) | LMNAKDM4ENPC1GAAMAPT | |
| SCHEMBL17757372 | 0.87 | KDM4E (0.34) | LMNAKDM4EMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016075137-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-05-19 | — | — | WO | disclosed |