Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757018 | 0.90 | LMNA (0.39) | GAARAB9ANPC1L3MBTL1LMNA | |
| SCHEMBL17757117 | 0.89 | ACAT2 (0.37) | GAARAB9ANPC1MAPTKDM4E | |
| SCHEMBL17757836 | 0.89 | HTT (0.38) | GAALMNAKDM4EHTTALDH1A1 | |
| SCHEMBL17757507 | 0.89 | ICMT (0.31) | — | |
| SCHEMBL17992096 | 0.88 | L3MBTL1 (0.33) | GAARAB9ANPC1L3MBTL1LMNA | |
| SCHEMBL17757737 | 0.88 | ACAT2 (0.33) | GAARAB9ANPC1MAPTKDM4E | |
| SCHEMBL17757357 | 0.87 | LMNA (0.31) | GAARAB9ANPC1LMNAMAPT | |
| SCHEMBL19523216 | 0.87 | PTPN1 (0.42) | GAARAB9ANPC1L3MBTL1LMNA | |
| SCHEMBL17757331 | 0.87 | MAPT (0.33) | L3MBTL1LMNAMAPTKDM4EHTT | |
| SCHEMBL17757335 | 0.87 | MAPT (0.35) | GAAL3MBTL1LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016075137-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-05-19 | — | — | WO | disclosed |