Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.58 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.58 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17758484 | 0.86 | ROCK2 (0.61) | TMEM97SIGMAR1ALDH1A1TP53KMT2A | |
| SCHEMBL19657230 | 0.85 | TMEM97 (0.56) | TMEM97SIGMAR1TLR9TLR8TLR7 | |
| SCHEMBL17758471 | 0.85 | SMPD1 (0.63) | TMEM97SIGMAR1TLR8TLR7ALDH1A1 | |
| SCHEMBL17676475 | 0.83 | LMNA (0.54) | TMEM97SIGMAR1ALDH1A1TP53KMT2A | |
| SCHEMBL20094150 | 0.82 | SMN1; SMN2 (0.55) | TMEM97SIGMAR1TLR9TLR8TLR7 | |
| SCHEMBL20682518 | 0.82 | TMEM97 (0.53) | TMEM97SIGMAR1TLR9TLR8TLR7 | |
| SCHEMBL19651848 | 0.82 | ALDH1A1 (0.53) | TMEM97SIGMAR1TLR9TLR8TLR7 | |
| SCHEMBL15656703 | 0.81 | ALDH1A1 (0.52) | TMEM97SIGMAR1TLR9TLR8TLR7 | |
| SCHEMBL1559022 | 0.81 | ALDH1A1 (0.52) | TMEM97SIGMAR1TLR9TLR8TLR7 | |
| SCHEMBL13575527 | 0.81 | ALDH1A1 (0.55) | TLR9TLR8TLR7ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077378-A1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |