SCHEMBL1775976

SCHEMBL1775976

COc1ccc2sc(Cc3cc(C4(O)O[C@H](COCc5ccccc5)[C@H](OCc5ccccc5)[C@@H](OCc5ccccc5)[C@H]4OCc4ccccc4)c4ccccc4c3)cc2c1

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CLK1 P49759 3/20 0.37
DYRK1A Q13627 1/20 0.33
SSTR4 P31391 2/20 0.32
PTPN2 P17706 1/20 0.30
PTPN1 P18031 1/20 0.30
TACR2 P21452 1/20 0.30
MTNR1A P48039 1/20 0.30
SSTR1 P30872 1/20 0.30
SSTR2 P30874 1/20 0.30
SSTR3 P32745 1/20 0.30
SSTR5 P35346 1/20 0.30
SLC5A2 P31639 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1775979 0.91 TACR2 (0.34) SSTR4TACR2SSTR1SSTR2SSTR3
SCHEMBL1774436 0.91 SLC5A2 (0.34) SSTR4PTPN2PTPN1TACR2SLC5A2
SCHEMBL1776117 0.89 TP53 (0.32) SSTR4SLC5A2
SCHEMBL1775301 0.89 TP53 (0.32) SSTR4SLC5A2
SCHEMBL1774673 0.82 SLC5A2 (0.34) TACR2SLC5A2
SCHEMBL1775540 0.81 SSTR4 (0.37) CLK1DYRK1ASSTR4PTPN2PTPN1
SCHEMBL2132859 0.80 PTPN1 (0.35) SSTR4PTPN2PTPN1TACR2
SCHEMBL12605359 0.79 HTR1A (0.34) SSTR4PTPN2PTPN1TACR2
SCHEMBL12605356 0.79 TACR2 (0.37) SSTR4PTPN2PTPN1TACR2SSTR1
SCHEMBL5517833 0.78 SLC5A2 (0.38) SSTR4PTPN1TACR2SSTR1SSTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7943748-B2 Glucitol derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2011-05-17 US disclosed
US-20080319047-A1 Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2008-12-25 US disclosed
EP-1803721-A1 NOVEL GLUCITOL DERIVATIVE, PRODRUG THEREOF AND SALT THEREOF, AND THERAPEUTIC AGENT CONTAINING THE SAME FOR DIABETES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2007-07-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080319047-A1 Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes SLC5A1, SLC5A2, GPR119 CLK1 3014/4885DYRK1A 2722/4885SSTR4 2895/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.