Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 13/20 | 0.57 |
| ▸ | CA1 | P00915 | 13/20 | 0.57 |
| ▸ | CA9 | Q16790 | 13/20 | 0.57 |
| ▸ | CA2 | P00918 | 11/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381729 | 0.79 | CA12 (0.86) | CA12CA1CA9CA2MGLL | |
| SCHEMBL11809610 | 0.77 | CA12 (0.45) | CA12CA1CA9CA2MGLL | |
| SCHEMBL2475352 | 0.77 | CA12 (0.91) | CA12CA1CA9CA2MGLL | |
| SCHEMBL2379653 | 0.77 | CA12 (0.91) | CA12CA1CA9CA2MGLL | |
| SCHEMBL2380360 | 0.77 | CA12 (0.91) | CA12CA1CA9CA2MGLL | |
| SCHEMBL2382500 | 0.77 | CA12 (0.91) | CA12CA1CA9CA2MGLL | |
| Potassium Ion SCHEMBL9359833 | 0.77 | CA12 (0.91) | CA12CA1CA9CA2MGLL | |
| Potassium Ion SCHEMBL10729103 | 0.77 | CA12 (0.91) | CA12CA1CA9CA2MGLL | |
| SCHEMBL7129253 | 0.77 | CA12 (0.83) | CA12CA1CA9CA2MGLL | |
| SCHEMBL4398000 | 0.77 | CA12 (0.91) | CA12CA1CA9CA2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112079-A1 | PHOSPHODIESTERASE INHIBITORS | THE GOV. OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICES | 2011-05-12 | — | — | US | disclosed |
| EP-2231669-A1 | PHOSPHODIESTERASE INHIBITORS | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009089027-A1 | PHOSPHODIESTERASE INHIBITORS | GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICE, NATIONAL INSTITUTES OF HEALTH (US) | 2009-07-16 | — | — | WO | disclosed |
| US-5162349-A | Mercaptobis/1,3,4-oxa- and -thiadiazoles/ | CIBA-GEIGY CORPORATION (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0364396-A1 | Neumaticides and fungicides | CIBA-GEIGY AG (CH) | 1990-04-18 | — | — | EP | disclosed |
| EP-0364395-A1 | Nematicides | CIBA-GEIGY AG (CH) | 1990-04-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112079-A1 | PHOSPHODIESTERASE INHIBITORS | PDE5A, PDE3B, PDE3A | CA12 3542/4885CA1 2560/4885CA9 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.