Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.39 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNG | P07510 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11451364 | 0.82 | KMT2A (0.46) | CCR2ALDH1A1SMN1; SMN2ALOX15TSHR | |
| SCHEMBL31687596 | 0.81 | TPMT (0.39) | KMT2AOPRM1SLC6A4 | |
| SCHEMBL1710788 | 0.81 | HSD11B1 (0.45) | CCR2KMT2AHSD11B1OPRM1SLC6A3 | |
| SCHEMBL31687568 | 0.79 | MAPT (0.42) | SMN1; SMN2KMT2ACHRNA1CHRNGCHRNB1 | |
| SCHEMBL2033743 | 0.78 | CFTR (0.47) | MAPK1KMT2ATET3FBXL19CXXC5 | |
| SCHEMBL31687658 | 0.78 | SRD5A2 (0.42) | ALDH1A1MAPK1SMN1; SMN2ALOX15KMT2A | |
| SCHEMBL10540765 | 0.77 | MAOA (0.38) | CCR2ALDH1A1MAPK1ALOX15TSHR | |
| SCHEMBL10889297 | 0.77 | MAOA (0.38) | CCR2ALDH1A1MAPK1ALOX15TSHR | |
| SCHEMBL10226585 | 0.76 | TET3 (0.48) | CCR2ALDH1A1MAPK1TP53SMN1; SMN2 | |
| SCHEMBL31687688 | 0.75 | MMP2 (0.47) | SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670731-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AND USES THEREOF. | BIONOMICS LTD (AU) | 2016-05-25 | — | — | EP | disclosed |