SCHEMBL17774591

SCHEMBL17774591

CS(=O)(=O)Nc1ccc(N)cc1S(=O)(=O)Nc1cccc2c(O)cccc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 2/20 0.58
KAT2B Q92831 2/20 0.58
KAT8 Q9H7Z6 2/20 0.58
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
GAA P10253 4/20 0.50
G6PD P11413 1/20 0.50
MAP1LC3B Q9GZQ8 1/20 0.50
ALDH1A1 P00352 2/20 0.46
TP53 P04637 2/20 0.46
MAPT P10636 2/20 0.46
HPGD P15428 2/20 0.46
ALOX15 P16050 2/20 0.46
CASP1 P29466 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
HSD17B10 Q99714 2/20 0.46
KDM4E B2RXH2 1/20 0.46
POLB P06746 1/20 0.46
PKM P14618 1/20 0.46
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4583715 0.81 EP300 (0.80) EP300KAT2BKAT8MEN1KMT2A
SCHEMBL30669737 0.75 EP300 (1.00) EP300KAT2BKAT8MEN1KMT2A
SCHEMBL15894583 0.75 EP300 (1.00) EP300KAT2BKAT8MEN1KMT2A
SCHEMBL6573116 0.72 EP300 (0.50) EP300KAT2BKAT8MEN1KMT2A
SCHEMBL11509065 0.72 KEAP1 (0.77) EP300KAT2BKAT8KMT2AGAA
Hydrochloric Acid SCHEMBL7160191 0.71 EP300 (0.49) EP300KAT2BKAT8MEN1KMT2A
SCHEMBL21777450 0.70 HKDC1 (0.56) EP300KAT2BKAT8MEN1KMT2A
SCHEMBL11420082 0.70 EDNRA (0.52) EP300KAT2BKAT8MEN1KMT2A
SCHEMBL23226730 0.69 ADRB3 (0.56) EP300KAT2BKAT8
SCHEMBL7028887 0.69 EP300 (0.55) EP300KAT2BKAT8KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9872822-B2 Process for dyeing in the presence of oxidation bases comprising at least one sulfonic, sulfonamide, sulfone, amid or acid group and a metal catalyst, device and ready-to-use composition L'OREAL (FR) 2018-01-23 US disclosed
US-9872822-B2 Process for dyeing in the presence of oxidation bases comprising at least one sulfonic, sulfonamide, sulfone, amid or acid group and a metal catalyst, device and ready-to-use composition L'OREAL (FR) 2018-01-23 US disclosed
US-20160143826-A1 PROCESS FOR DYEING IN THE PRESENCE OF OXIDATION BASES COMPRISING AT LEAST ONE SULFONIC, SULFONAMIDE, SULFONE, AMID OR ACID GROUP AND A METAL CATALYST, DEVICE AND READY-TO-USE COMPOSITION L'OREAL (FR) 2016-05-26 US disclosed
US-20160143826-A1 PROCESS FOR DYEING IN THE PRESENCE OF OXIDATION BASES COMPRISING AT LEAST ONE SULFONIC, SULFONAMIDE, SULFONE, AMID OR ACID GROUP AND A METAL CATALYST, DEVICE AND READY-TO-USE COMPOSITION L'OREAL (FR) 2016-05-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160143826-A1 PROCESS FOR DYEING IN THE PRESENCE OF OXIDATION BASES COMPRISING AT LEAST ONE SULFONIC, SULFONAMIDE, SULFONE, AMID OR ACID GROUP AND A METAL CATALYST, DEVICE AND READY-TO-USE COMPOSITION KRT18, ARSA, SQOR EP300 4197/4885KAT2B 289/4885KAT8 458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.