Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 6/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17776353 | 1.00 | OPRD1 (0.70) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL17776355 | 0.85 | OPRK1 (0.64) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL17776361 | 0.85 | OPRK1 (0.64) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL17776360 | 0.84 | OPRD1 (0.56) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Ici-199,441 SCHEMBL7062272 | 0.84 | OPRD1 (0.98) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Ici-199,441 SCHEMBL7647023 | 0.84 | OPRD1 (0.98) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL17776362 | 0.83 | OPRK1 (0.56) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Ici-199,441 SCHEMBL6639282 | 0.82 | OPRD1 (1.00) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Ici-199,441 SCHEMBL7640991 | 0.82 | OPRD1 (1.00) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL17570385 | 0.81 | OPRD1 (0.98) | OPRD1OPRM1OPRK1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11111214-B2 | Kappa opioid agonists and uses thereof | NEKTAR THERAPEUTICS (US) | 2021-09-07 | — | — | US | disclosed |
| US-20190352291-A1 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS | 2019-11-21 | — | — | US | disclosed |
| US-10407416-B2 | Kappa opioid agonists and uses thereof | NEKTAR THERAPEUTICS (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180016266-A1 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS | 2018-01-18 | — | — | US | disclosed |
| US-20180016266-A1 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS | 2018-01-18 | — | — | US | disclosed |
| US-9815824-B2 | Kappa opioid agonists and uses thereof | NEKTAR THERAPEUTICS (US) | 2017-11-14 | — | — | US | disclosed |
| US-9815824-B2 | Kappa opioid agonists and uses thereof | NEKTAR THERAPEUTICS (US) | 2017-11-14 | — | — | US | disclosed |
| US-20160145245-A1 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS | 2016-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145245-A1 | KAPPA OPIOID AGONISTS AND USES THEREOF | OPRK1, OPRD1, OPRM1 | OPRD1 2/4885OPRM1 3/4885OPRK1 1/4885 |
| US-20190352291-A1 | KAPPA OPIOID AGONISTS AND USES THEREOF | OPRK1, OPRD1, OPRM1 | OPRD1 2/4885OPRM1 3/4885OPRK1 1/4885 |
| US-11111214-B2 | Kappa opioid agonists and uses thereof | OPRK1, OPRD1, OPRM1 | OPRD1 2/4885OPRM1 3/4885OPRK1 1/4885 |
| US-20180016266-A1 | KAPPA OPIOID AGONISTS AND USES THEREOF | OPRK1, OPRD1, OPRL1 | OPRD1 2/4885OPRM1 4/4885OPRK1 1/4885 |
| US-10407416-B2 | Kappa opioid agonists and uses thereof | OPRK1, OPRD1, OPRL1 | OPRD1 2/4885OPRM1 4/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.