Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ici-199,441. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 9/20 | 0.98 |
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.98 |
| ▸ | OPRK1 known ✓ | P41145 | 3/20 | 0.98 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | TP53 | P04637 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.98 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ici-199,441 SCHEMBL7647023 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Ici-199,441 SCHEMBL7640991 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Ici-199,441 SCHEMBL6639282 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL17570398 | 0.98 | OPRD1 (0.98) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL17570385 | 0.98 | OPRD1 (0.98) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Ici-199,441 SCHEMBL26981188 | 0.97 | OPRD1 (0.96) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL21468950 | 0.92 | OPRK1 (0.86) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| SCHEMBL21120210 | 0.90 | OPRK1 (0.83) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL9457250 | 0.89 | OPRD1 (1.00) | OPRD1OPRM1OPRK1ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL9457257 | 0.89 | OPRD1 (1.00) | OPRD1OPRM1OPRK1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327444-A1 | Antipruritic agent | TORAY INDUSTRIES, INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-1312361-A1 | Antipruritic agent | TORAY INDUSTRIES, INC. (JP) | 2003-05-21 | — | — | EP | disclosed |
| EP-1310251-A1 | Antipruritic agent | TORAY INDUSTRIES, INC. (JP) | 2003-05-14 | — | — | EP | disclosed |
| EP-1310255-A1 | Antipruritic agent | TORAY INDUSTRIES, INC. (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6468971-B1 | Maintaining kidney function during surgery or trauma | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2002-10-22 | — | — | US | disclosed |
| US-20020137760-A1 | Antipruritic | TORAY INDUSTRIES, INC. | 2002-09-26 | — | — | US | disclosed |
| US-6316461-B1 | ADMINISTERING OPIATE K RECEPTOR AGONIST | TORAY INDUSTRIES, INC. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6174891-B1 | A MORPHINAN DERIVTIVE AS A POTENT AND FAST-ACTING OPIATE KAPPA RECEPTOR FOR THE RELIEF OF PURITIS DUE TO DERMATOSES WITH INFLAMMATION OR AN INTERNAL DISEASE (MALIGNANT TUMORS, DIABETES MELLITUS, HEPATIC DISEASES, GOUT; RENAL FAILURE | TORAY INDUSTRIES, INC. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0897726-A1 | ANTIPRURITIC AGENT | TORAY INDUSTRIES, INC. (JP) | 1999-02-24 | — | — | EP | disclosed |
| US-5859043-A | Method for maintaining kidney function during surgery or severe trauma under general anesthesia | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 1999-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137760-A1 | Antipruritic | ITCH, MRGPRX2, MRGPRX4 | OPRD1 9/4885OPRM1 19/4885OPRK1 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.