Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777765 | 1.00 | CES2 (0.52) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL8250615 | 1.00 | CES2 (0.52) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL2011191 | 0.78 | CES2 (0.56) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL16958562 | 0.78 | CES2 (0.44) | CES2CES1 | |
| SCHEMBL14183687 | 0.78 | CES2 (0.44) | CES2CES1 | |
| SCHEMBL17046391 | 0.78 | CES2 (0.44) | CES2CES1 | |
| SCHEMBL6028666 | 0.77 | CES2 (0.46) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL6028679 | 0.77 | CES2 (0.46) | CES2CES1PARP1HDAC1HDAC6 | |
| SCHEMBL31204251 | 0.77 | PARP1 (0.50) | PARP1GRIN2BCTSLMEN1KMT2A | |
| SCHEMBL11075718 | 0.77 | CES2 (0.54) | CES2CES1PARP1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12319664-B2 | Herbicidally active 3-phenylisoxazoline-5-carboxamides of cyclopentenylcarboxylic acid derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2025-06-03 | — | — | US | disclosed |
| WO-2025085347-A1 | IL4I1 INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2025-04-24 | — | — | WO | disclosed |
| US-12185723-B2 | Herbicidally active 3-phenylisoxazoline-5-carboxamides of s-containing cyclopentenylcarboxylic esters | BAYER AKTIENGESELLSCHAFT (DE) | 2025-01-07 | — | — | US | disclosed |
| US-20240376089-A1 | 3-HYDROXY-5-(ISOXAZOL-5-YL) PYRIDINE FORMYLGLYCINE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | CHINA PHARMACEUTICAL UNIVERSITY (CN) | 2024-11-14 | — | — | US | disclosed |
| CN-116535399-B | 3-hydroxy-5- (isoxazol-5-yl) pyridine formyl glycine compound, preparation method, pharmaceutical composition and application | 中国药科大学 | 2024-02-27 | — | — | CN | disclosed |
| CN-116535399-A | 3-hydroxy-5- (isoxazol-5-yl) pyridine formyl glycine compound, preparation method, pharmaceutical composition and application | 中国药科大学 | 2023-08-04 | — | — | CN | disclosed |
| WO-2023142214-A1 | 3-HYDROXY-5-(ISOXAZOL-5-YL) PYRIDINE FORMYLGLYCINE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | 中国药科大学 | 2023-08-03 | — | — | WO | disclosed |
| EP-3937637-B1 | HERBICIDAL 3-PHENYLISOXAZOLIN-5-CARBOXAMIDES OF S-CONTAINING CYCLOPENTENYL CARBOXYLIC ACID ESTERS | BAYER AG (DE) | 2023-04-19 | — | — | EP | disclosed |
| EP-3743411-B1 | HERBICIDAL 3-PHENYLISOXAZOLIN-5-CARBOXAMIDES OF CYCLOPENTENYL CARBOXYLIC ACID DERIVATIVES | BAYER AG (DE) | 2022-12-21 | — | — | EP | disclosed |
| US-20220306591-A1 | HERBICIDALLY ACTIVE 3-PHENYLISOXAZOLINE-5-CARBOXAMIDES OF CYCLOPENTENYLCARBOXYLIC ACID DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2022-09-29 | — | — | US | disclosed |
| US-7538132-B2 | Isoxazolo derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-05-26 | — | — | US | disclosed |
| EP-1931661-B1 | ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-11-19 | — | — | EP | disclosed |
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| CN-101263139-A | Isoxazolo derivatives as GABA A alpha5 inverse agonists | HOFFMANN LA ROCHE (CH) | 2008-09-10 | — | — | CN | disclosed |
| US-7414061-B2 | Aryl-isoxazol-4-yl-imidazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1931661-A1 | ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-18 | — | — | EP | disclosed |
| US-20070161654-A1 | Aryl-isoxazol-4-yl-imidazole derivatives | HOFFMANN-LA ROCHE INC. | 2007-07-12 | — | — | US | disclosed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007039389-A1 | ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-12 | — | — | WO | disclosed |
| US-20070066668-A1 | Isoxazolo derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161654-A1 | Aryl-isoxazol-4-yl-imidazole derivatives | GABRA5, GABRA4, GABRA1 | CES2 3179/4885CES1 1483/4885PARP1 4578/4885 |
| US-12319664-B2 | Herbicidally active 3-phenylisoxazoline-5-carboxamides of cyclopentenylcarboxylic acid derivatives | AADAC, PRDX5, DDT | CES2 89/4885CES1 126/4885PARP1 3135/4885 |
| US-12185723-B2 | Herbicidally active 3-phenylisoxazoline-5-carboxamides of s-containing cyclopentenylcarboxylic esters | NOTUM, AADAC, DDT | CES2 42/4885CES1 71/4885PARP1 2563/4885 |
| US-20240376089-A1 | 3-HYDROXY-5-(ISOXAZOL-5-YL) PYRIDINE FORMYLGLYCINE COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | HIF1AN, HIF1A, EGLN3 | CES2 4360/4885CES1 2206/4885PARP1 2393/4885 |
| US-20220306591-A1 | HERBICIDALLY ACTIVE 3-PHENYLISOXAZOLINE-5-CARBOXAMIDES OF CYCLOPENTENYLCARBOXYLIC ACID DERIVATIVES | AADAC, PRDX5, DDT | CES2 89/4885CES1 126/4885PARP1 3135/4885 |
| US-20070066668-A1 | Isoxazolo derivatives | GABRA5, GABRA4, GABRA1 | CES2 2382/4885CES1 985/4885PARP1 3518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.