Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.36 |
| ▸ | WNT3A | P56704 | 4/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.32 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754455 | 1.00 | USP30 (0.36) | USP30WNT3AABL1IRAK4DYRK1A | |
| SCHEMBL16754404 | 0.89 | WNT3A (0.34) | USP30WNT3AABL1IRAK4DYRK1A | |
| SCHEMBL17618708 | 0.88 | USP30 (0.34) | USP30WNT3A | |
| SCHEMBL16754671 | 0.87 | HRH3 (0.38) | USP30WNT3AABL1GRM5KDM4E | |
| SCHEMBL16754289 | 0.86 | MAPK1 (0.34) | USP30WNT3AABL1DYRK1AMAPK1 | |
| SCHEMBL17778384 | 0.85 | L3MBTL1 (0.35) | USP30WNT3AABL1IRAK4KDM4E | |
| SCHEMBL16754615 | 0.85 | L3MBTL1 (0.35) | USP30WNT3AABL1IRAK4KDM4E | |
| SCHEMBL17618513 | 0.85 | HCRTR1 (0.42) | WNT3AABL1SCDGRM5MAPK1 | |
| SCHEMBL16754574 | 0.85 | WNT3A (0.41) | USP30WNT3AABL1GRM5 | |
| SCHEMBL17778222 | 0.85 | WNT3A (0.41) | USP30WNT3AABL1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |