Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CCND1 | P24385 | 4/20 | 0.41 |
| ▸ | CSF1R | P07333 | 4/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | FYN | P06241 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17780478 | 1.00 | CDK9 (0.41) | CDK9CDK4CCND1CSF1RCCNT1 | |
| SCHEMBL17780416 | 0.90 | CDK9 (0.40) | CDK9CDK4CCND1CSF1RCCNT1 | |
| SCHEMBL17780419 | 0.90 | CDK9 (0.40) | CDK9CDK4CCND1CSF1RCCNT1 | |
| SCHEMBL17780480 | 0.88 | PLK1 (0.39) | NUAK1BRD4TAF1PLK1TBK1 | |
| SCHEMBL17780482 | 0.88 | PLK1 (0.39) | NUAK1BRD4TAF1PLK1TBK1 | |
| SCHEMBL17780372 | 0.86 | ALK (0.35) | CSF1RFYNRETFGFR1FLT3 | |
| SCHEMBL17780376 | 0.86 | ALK (0.35) | CSF1RFYNRETFGFR1FLT3 | |
| SCHEMBL17780449 | 0.86 | BRD4 (0.39) | BRD4TAF1LRRK2JAK2PLK1 | |
| SCHEMBL17780436 | 0.85 | CDK4 (0.44) | CDK9CDK4CCND1CSF1RCCNT1 | |
| SCHEMBL17780495 | 0.84 | CDK9 (0.39) | CDK9CDK4CCND1CSF1RCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | claimed |