Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 11/20 | 0.77 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.57 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777862 | 0.95 | GABRA5 (0.75) | GABRA5ENPP2GABRA1 | |
| SCHEMBL1780012 | 0.91 | GABRA5 (0.76) | GABRA5ENPP2GABRA1ITGA5 | |
| SCHEMBL2929692 | 0.87 | GABRA5 (1.00) | GABRA5ITGA5 | |
| SCHEMBL1777170 | 0.85 | GABRA5 (0.75) | GABRA5ENPP2GABRA1ITGA5 | |
| SCHEMBL1777356 | 0.85 | GABRA5 (0.73) | GABRA5ENPP2GABRA1 | |
| SCHEMBL1778361 | 0.84 | GABRA5 (0.77) | GABRA5ENPP2GABRA1ITGA5 | |
| SCHEMBL286336 | 0.83 | GABRA5 (0.71) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1776643 | 0.83 | GABRA1 (0.80) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1778670 | 0.83 | ENPP2 (0.68) | GABRA5ENPP2GABRA1 | |
| SCHEMBL1778131 | 0.83 | ENPP2 (0.67) | GABRA5ENPP2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | disclosed |