Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.57 |
| ▸ | CES1 | P23141 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38662145 | 0.82 | LMNA (0.52) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL17784363 | 0.80 | LMNA (0.47) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL7763783 | 0.78 | CES2 (0.59) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL29185031 | 0.78 | CES2 (0.49) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL8591841 | 0.77 | CES2 (0.57) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL27517569 | 0.77 | LMNA (0.57) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL959019 | 0.77 | CES2 (0.57) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL10781088 | 0.77 | LMNA (0.57) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL9744991 | 0.77 | CES2 (0.57) | CES2CES1LMNATDP1L3MBTL1 | |
| SCHEMBL9805372 | 0.76 | LMNA (0.55) | CES2CES1LMNATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9629830-B2 | EphA4 inhibitors as neuroprotective agents | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2017-04-25 | — | — | US | disclosed |
| US-20160152618-A1 | EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152618-A1 | EphA4 INHIBITORS AS NEUROPROTECTIVE AGENTS | EPHA4, EPHA1, EPHA7 | CES2 949/4885CES1 1131/4885LMNA 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.