Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23116701 | 0.89 | TSHR (0.58) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL6610000 | 0.86 | TSHR (0.49) | TSHRMAPTALOX15THRBTP53 | |
| SCHEMBL19627154 | 0.86 | MAPT (0.60) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL23115272 | 0.85 | KMT2A (0.60) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL31425808 | 0.84 | MEN1 (0.47) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL24950408 | 0.84 | MEN1 (0.47) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL8175604 | 0.84 | MEN1 (0.47) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL31426191 | 0.84 | MEN1 (0.47) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL23115223 | 0.83 | MEN1 (0.46) | TSHRMEN1KMT2APOLBGAA | |
| SCHEMBL17785137 | 0.83 | MTNR1A (0.57) | TSHRMAPTMTNR1AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4740944-A2 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H-[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | Actuate Therapeutics Inc. (US) | 2026-05-13 | — | — | EP | disclosed |
| US-20250122213-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-04-17 | — | — | US | disclosed |
| US-20250115615-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS, INC. | 2025-04-10 | — | — | US | disclosed |
| US-20250115616-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS INC. | 2025-04-10 | — | — | US | disclosed |
| US-12195478-B2 | Opioid receptor modulators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-01-14 | — | — | US | disclosed |
| EP-4487913-A2 | OPIOID RECEPTOR MODULATORS | The Trustees Of Columbia University In The City Of New York (US) | 2025-01-08 | — | — | EP | disclosed |
| US-12145943-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS INC. (US) | 2024-11-19 | — | — | US | disclosed |
| US-12116374-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS INC. (US) | 2024-10-15 | — | — | US | disclosed |
| EP-3224261-B1 | OPIOID RECEPTOR MODULATORS | UNIV COLUMBIA (US) | 2024-09-18 | — | — | EP | disclosed |
| CN-111247153-B | Solid forms of 3- (5-fluorobenzofuran-3-yl) -4- (5-methyl-5H- [1,3] dioxolo [4,5-f ] indol-7-yl) pyrrole-2,5-dione | 开动疗法公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2019079299-A1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H-[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | ACTUATE THERAPEUTICS INC. (US) | 2019-04-25 | — | — | WO | disclosed |
| WO-2019079299-A1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H-[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | ACTUATE THERAPEUTICS INC. (US) | 2019-04-25 | — | — | WO | disclosed |
| WO-2019032958-A1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | ACTUATE THERAPEUTICS INC. (US) | 2019-02-14 | — | — | WO | disclosed |
| WO-2019032958-A1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | ACTUATE THERAPEUTICS INC. (US) | 2019-02-14 | — | — | WO | disclosed |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-11-23 | — | — | US | disclosed |
| EP-3224261-A1 | OPIOID RECEPTOR MODULATORS | The Trustees of Columbia University in the City of New York (US) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016086158-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-06-02 | — | — | WO | disclosed |
| WO-2016086158-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12145943-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | TSHR 2630/4885MEN1 3487/4885KMT2A 2759/4885 |
| US-12195478-B2 | Opioid receptor modulators | OPRM1, OPRL1, OPRD1 | TSHR 266/4885MEN1 4819/4885KMT2A 1891/4885 |
| US-20170334923-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | TSHR 312/4885MEN1 4864/4885KMT2A 1649/4885 |
| US-20250115616-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | TSHR 2630/4885MEN1 3487/4885KMT2A 2759/4885 |
| US-12116374-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | TSHR 2630/4885MEN1 3487/4885KMT2A 2759/4885 |
| US-20250115615-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | VHL, DHPS, PDCD5 | TSHR 2366/4885MEN1 3293/4885KMT2A 2903/4885 |
| US-20250122213-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | TSHR 266/4885MEN1 4819/4885KMT2A 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.