Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 8/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786597 | 0.91 | TTR (0.49) | TTRFTOTAS2R14FABP4MEN1 | |
| SCHEMBL14870530 | 0.78 | KDM4E (0.56) | POLBMAPTTTRTAS2R14FABP4 | |
| SCHEMBL4327511 | 0.76 | NPC1 (0.54) | NPC1MAPTRAB9ATTRTAS2R14 | |
| SCHEMBL17786361 | 0.73 | TTR (0.51) | TTRFTOTAS2R14FABP4MEN1 | |
| SCHEMBL10385663 | 0.72 | MEN1 (0.72) | NPC1MAPTRAB9ATTRFTO | |
| SCHEMBL11611911 | 0.71 | TTR (0.67) | NPC1MAPTRAB9ATTRFTO | |
| SCHEMBL1649780 | 0.71 | TTR (0.62) | NPC1MAPTRAB9ATTRFTO | |
| SCHEMBL18109767 | 0.71 | FABP4 (0.85) | MAPTTTRTAS2R14FABP4MEN1 | |
| SCHEMBL17786362 | 0.71 | TTR (0.51) | POLBTTRFTOTAS2R14FABP4 | |
| SCHEMBL10144151 | 0.70 | FABP4 (0.62) | NPC1MAPTTTRFTOTAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083490-A1 | COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES | REMYND NV (BE) | 2016-06-02 | — | — | WO | disclosed |