Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 9/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1890227 | 0.92 | PARP1 (0.48) | PARP1PTGESHDAC3HDAC7HDAC10 | |
| SCHEMBL1892116 | 0.80 | PIK3C2B (0.52) | PARP1PTGESHDAC3HDAC7HDAC10 | |
| SCHEMBL12662375 | 0.75 | PTGES (0.46) | PARP1PTGESHDAC3HDAC7HDAC10 | |
| SCHEMBL1888653 | 0.74 | PARP1 (0.53) | PARP1 | |
| SCHEMBL12662378 | 0.74 | PTGES (0.44) | PARP1PTGESHDAC3HDAC7HDAC10 | |
| SCHEMBL12662376 | 0.74 | PTGES (0.51) | PARP1PTGES | |
| SCHEMBL1889697 | 0.73 | LMNA (0.50) | PARP1PTGESHDAC3HDAC7HDAC10 | |
| SCHEMBL1688037 | 0.72 | ALDH1A1 (0.44) | PARP1PTGESCYP2C9 | |
| SCHEMBL1895826 | 0.72 | PARP1 (0.56) | PARP1HDAC3HDAC7HDAC10HDAC6 | |
| SCHEMBL1888077 | 0.71 | PARP1 (0.55) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315763-B1 | BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-06-01 | — | — | EP | disclosed |