Ergocristine

Ergocristine

SCHEMBL177877

CC(C)[C@@]1(NC(=O)[C@@H]2C=C3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 11/20 1.00
MAPT P10636 10/20 1.00
MEN1 O00255 9/20 1.00
KMT2A Q03164 9/20 1.00
CYP2C19 P33261 9/20 1.00
KDM4E B2RXH2 7/20 1.00
ALDH1A1 P00352 6/20 1.00
ABCB1 P08183 6/20 1.00
HIF1A Q16665 5/20 1.00
HPGD P15428 5/20 1.00
HSD17B10 Q99714 4/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
THRB P10828 2/20 1.00
CYP3A4 P08684 10/20 0.86
USP2 O75604 5/20 0.86
ADRA2A P08913 5/20 0.86
DRD2 P14416 5/20 0.86
ADRA2B P18089 5/20 0.86
ADRA2C P18825 5/20 0.86
DRD1 P21728 5/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ergocristine SCHEMBL4947691 1.00 CYP2C9 (1.00) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocristine SCHEMBL30957132 1.00 CYP2C9 (1.00) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocristine SCHEMBL455906 1.00 CYP2C9 (1.00) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocristine SCHEMBL14029486 1.00 CYP2C9 (1.00) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocristine SCHEMBL20136277 0.98 CYP2C9 (0.96) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocristine SCHEMBL11081603 0.98 CYP2C9 (0.96) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocristine SCHEMBL18208064 0.98 CYP2C9 (0.96) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocristine SCHEMBL29386896 0.94 MAPT (0.89) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocryptine SCHEMBL78951 0.92 KDM4E (1.00) CYP2C9MAPTMEN1KMT2ACYP2C19
Ergocryptine SCHEMBL11034170 0.92 KDM4E (1.00) CYP2C9MAPTMEN1KMT2ACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 841 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026043908-A1 COMPOSITIONS AND METHODS TO IMPROVE SEQUESTRATION OF MYCOTOXINS AND THEIR USE IN DETOXIFICATION OF ANIMAL FEED AND ANIMAL PRODUCTION SYSTEMS ALLTECH, INC. (US) 2026-02-26 WO claimed
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP claimed
EP-4620936-A1 PROCESS FOR THE PREPARATION OF N6-ISOTOPE-LABELED ERGOT ALKALOIDS, IN PARTICULAR LYSERGIC ACID AMIDES AND ERGOPEPTINES Bundesrepublik Deutschland, vertreten durch den Bundesminister für Wirtschaft und Klimaschutz, dieser vertreten durch den Präsidenten der (DE) 2025-09-24 EP claimed
US-20250152591-A1 TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH MENIN INHIBITORS AND P-GLYCOPROTEIN INHIBITORS KURA ONCOLOGY INC (US) 2025-05-15 US claimed
EP-4472637-A1 TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH MENIN INHIBITORS AND P-GLYCOPROTEIN INHIBITORS Kura Oncology, Inc. (US) 2024-12-11 EP claimed
WO-2023150635-A1 TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH MENIN INHIBITORS AND P-GLYCOPROTEIN INHIBITORS KURA ONCOLOGY, INC. (US) 2023-08-10 WO claimed
EP-4220161-A1 A BUFFER SYSTEM FOR PARTICLE-BASED MULTIPLEXED IMMUNOASSAYS Bundesrepublik Deutschland, vertreten durch den Bundesminister für Wirtschaft und Energie (DE) 2023-08-02 EP claimed
US-20200222386-A1 AGENT FOR PREVENTING AND/OR TREATING ALZHEIMER'S DISEASE KYOTO UNIVERSITY (JP) 2020-07-16 US claimed
EP-3646872-A1 AGENT FOR PREVENTING AND/OR TREATING ALZHEIMER'S DISEASE Kyoto University (JP) 2020-05-06 EP claimed
WO-2002089798-A2 METHOD AND COMPOSITIONS FOR TREATING MIGRAINES MERCK & CO., INC. (US) 2002-11-14 WO claimed
US-20020143007-A1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use GARVEY DAVID S (US) 2002-10-03 US claimed
EP-1018879-A4 NITROSATED AND NITROSYLATED ALPHA-ADRENERGIC RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS AND THEIR USES NITROMED INC (US) 2002-07-24 EP claimed
WO-2002024865-A2 MODULATION OF SECONDARY METABOLITE PRODUCTION BY ZINC BINUCLEAR CLUSTER PROTEINS MICROBIA, INC. (US) 2002-03-28 WO claimed
EP-1109542-A1 NITROSATED AND NITROSYLATED ALPHA-ADRENERGIC RECEPTOR ANTAGONISTS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2001-06-27 EP claimed
EP-1018879-A1 NITROSATED AND NITROSYLATED ALPHA-ADRENERGIC RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS AND THEIR USES Nitromed, Inc. (US) 2000-07-19 EP claimed
WO-2000012075-A1 NITROSATED AND NITROSYLATED ALPHA-ADRENERGIC RECEPTOR ANTAGONISTS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2000-03-09 WO claimed
WO-1997027749-A1 NITROSATED AND NITROSYLATED α-ADRENERGIC RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS AND THEIR USES NITROMED, INC. (US) 1997-08-07 WO claimed
US-5573776-A Oral osmotic device with hydrogel driving member ALZA CORPORATION (US) 1996-11-12 US claimed
US-5468486-A Vaccine containing a protein alkaloid conjugate for the treatment of fescue toxicosis THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 1995-11-21 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250152591-A1 TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH MENIN INHIBITORS AND P-GLYCOPROTEIN INHIBITORS MEN1, ABCB1, ABCC1 CYP2C9 3224/4885MAPT 3308/4885MEN1 1/4885
US-20020143007-A1 Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use ADRB1, ADRB3, ADRA1D CYP2C9 583/4885MAPT 126/4885MEN1 3390/4885
US-20200222386-A1 AGENT FOR PREVENTING AND/OR TREATING ALZHEIMER'S DISEASE PSEN1, APP, PSEN2 CYP2C9 4620/4885MAPT 6/4885MEN1 1698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.