Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.62 |
| ▸ | HTR3B | O95264 | 1/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HTR3A | P46098 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 1/20 | 0.62 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.62 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.59 |
| ▸ | HTR2C | P28335 | 6/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13648739 | 0.90 | DRD2 (0.65) | DRD2DRD3HTR1AADRA1DADRA1A | |
| Ammonia Solution, Strong SCHEMBL2320933 | 0.89 | DRD2 (0.64) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL13698446 | 0.86 | DRD2 (0.61) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL1777570 | 0.85 | DRD2 (0.55) | DRD2DRD3HTR3EHTR3BADRB1 | |
| SCHEMBL4915562 | 0.84 | DRD2 (0.59) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL4915560 | 0.84 | DRD2 (0.59) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL7790707 | 0.81 | SLC6A2 (0.66) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL7801405 | 0.80 | DRD2 (0.55) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL3556792 | 0.80 | DRD2 (0.68) | DRD2DRD3HTR3EHTR3BADRB1 | |
| SCHEMBL13698442 | 0.80 | DRD2 (0.57) | DRD2DRD3HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943768-B2 | Piperazine compounds useful as antagonists of C-C chemokines (Ccr2b and CcrS) for the treatment of inflammatory diseases | ASTRAZENECA AB (SE) | 2011-05-17 | — | — | US | claimed |
| US-20010014680-A1 | 1,4-piperazine derivatives | WYETH | 2001-08-16 | — | — | US | claimed |
| US-6255302-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-03 | — | — | US | claimed |
| US-10113049-B2 | Thermoplastic resin composition | NIPPON NYUKAZAI CO., LTD. (JP) | 2018-10-30 | — | — | US | disclosed |
| CN-104159977-B | Thermoplastic resin composition | 日本乳化剂株式会社 | 2017-09-12 | — | — | CN | disclosed |
| US-20150329698-A1 | THERMOPLASTIC RESIN COMPOSITION | NIPPON NYUKAZAI CO., LTD. (JP) | 2015-11-19 | — | — | US | disclosed |
| CN-104159977-A | Thermoplastic resin composition | NIPPON NYUKAZAI CO LTD | 2014-11-19 | — | — | CN | disclosed |
| EP-1140838-A1 | 1, 4-PIPERAZINE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| US-20010014680-A1 | 1,4-piperazine derivatives | WYETH | 2001-08-16 | — | — | US | disclosed |
| US-6255302-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-03 | — | — | US | disclosed |
| WO-2000035878-A1 | 1,4-PIPERAZINE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010014680-A1 | 1,4-piperazine derivatives | ADH1A, ADH1C, SNCA | DRD2 12/4885DRD3 32/4885HTR3E 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.