Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 4/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HRH2 | P25021 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9225440 | 0.88 | MAPK1 (0.81) | MAPK1DRD4ADRA1DADRA1AADRA1B | |
| SCHEMBL13648739 | 0.87 | DRD2 (0.65) | SLC6A2SLC6A4DRD4ADRA1DADRA1A | |
| SCHEMBL7800271 | 0.86 | MEN1 (0.57) | SLC6A2SLC6A4MAPK1DRD4ADRA1D | |
| Ammonia Solution, Strong SCHEMBL2320933 | 0.86 | DRD2 (0.64) | SLC6A2SLC6A4DRD4ADRA1DADRA1A | |
| SCHEMBL3563737 | 0.84 | KDM4E (0.64) | SLC6A2SLC6A4MAPK1DRD4ADRA1D | |
| SCHEMBL13698446 | 0.83 | DRD2 (0.61) | DRD4ADRA1DADRA1AADRA1BHTR1A | |
| Hydrochloric Acid SCHEMBL3710903 | 0.83 | KDM4E (0.62) | SLC6A2SLC6A4MAPK1DRD4ADRA1D | |
| SCHEMBL1779199 | 0.81 | DRD2 (0.62) | SLC6A2SLC6A4DRD4ADRA1DADRA1A | |
| SCHEMBL4915560 | 0.81 | DRD2 (0.59) | SLC6A2SLC6A4DRD4ADRA1DADRA1A | |
| SCHEMBL4915562 | 0.81 | DRD2 (0.59) | SLC6A2SLC6A4DRD4ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010014680-A1 | 1,4-piperazine derivatives | WYETH | 2001-08-16 | — | — | US | claimed |
| US-6255302-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-03 | — | — | US | claimed |
| US-20010014680-A1 | 1,4-piperazine derivatives | WYETH | 2001-08-16 | — | — | US | disclosed |
| US-6255302-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010014680-A1 | 1,4-piperazine derivatives | ADH1A, ADH1C, SNCA | SLC6A2 218/4885SLC6A4 245/4885MAPK1 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.