SCHEMBL17799681

SCHEMBL17799681

O=C(N[C@H]1CC[C@H]1c1ccc(Cl)cc1Cl)c1ccccc1OC(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PNLIP P16233 1/20 0.47
▸ KCNK3 O14649 4/20 0.43
▸ KCNK9 Q9NPC2 4/20 0.43
▸ MGLL Q99685 2/20 0.43
▸ ANO1 Q5XXA6 2/20 0.41
▸ ACKR3 P25106 1/20 0.40
▸ RXFP1 Q9HBX9 1/20 0.40
▸ F2R P25116 1/20 0.40
▸ OPRM1 P35372 1/20 0.40
▸ P2RX1 P51575 1/20 0.40
▸ AVPR2 P30518 1/20 0.39
▸ GPR27 Q9NS67 1/20 0.39
▸ KDM5A P29375 1/20 0.39
▸ SLC6A12 P48065 1/20 0.39
▸ HCRTR1 O43613 1/20 0.38
▸ HSD17B13 Q7Z5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16372208 1.00 PNLIP (0.47) PNLIPKCNK3KCNK9MGLLANO1
SCHEMBL17799745 0.86 KDM4E (0.49) —
SCHEMBL16372266 0.85 MGLL (0.48) PNLIPKCNK3KCNK9MGLLANO1
SCHEMBL17799723 0.85 MGLL (0.48) PNLIPKCNK3KCNK9MGLLANO1
SCHEMBL16451641 0.84 HCRTR1 (0.45) KCNK3KCNK9MGLLSLC6A12HCRTR1
SCHEMBL17799670 0.84 HCRTR1 (0.45) KCNK3KCNK9MGLLSLC6A12HCRTR1
SCHEMBL15295033 0.84 HCRTR1 (0.45) KCNK3KCNK9MGLLSLC6A12HCRTR1
SCHEMBL15295032 0.84 HCRTR1 (0.45) KCNK3KCNK9MGLLSLC6A12HCRTR1
SCHEMBL16451640 0.84 HCRTR1 (0.45) KCNK3KCNK9MGLLSLC6A12HCRTR1
SCHEMBL17799743 0.83 SLC6A12 (0.47) SLC6A12HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50724-E1 4-membered ring carboxamides used as nematicides SYNGENTA CROP PROTECTION AG (CH) 2026-01-06 — — US disclosed
EP-3019476-B1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-17 — — EP disclosed
US-9867371-B2 4-membered ring carboxamides used as nematicides SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 — — US disclosed
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2016-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES TUBA3C, DDT, CYCS PNLIP 4159/4885KCNK3 2359/4885KCNK9 2714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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