SCHEMBL1779971

SCHEMBL1779971

COC(=O)n1cnc(C[C@@H](C)N)c1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CPB2 Q96IY4 20/20 0.40
CPB1 P15086 9/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL594580 0.83 CPB2 (0.42) CPB2CPB1
SCHEMBL1071999 0.82 CPB2 (0.40) CPB2CPB1
Hydrochloric Acid SCHEMBL11418503 0.81 CPB2 (0.41) CPB2CPB1
Hydrochloric Acid SCHEMBL1521823 0.81 CPB2 (0.41) CPB2CPB1
Hydrochloric Acid SCHEMBL3428343 0.80 CPB2 (0.40) CPB2CPB1
SCHEMBL14571377 0.79 LPO (0.37) CPB2CPB1
SCHEMBL6975846 0.79 CYP3A4 (0.32) CPB2CPB1
SCHEMBL30786466 0.75 CPB2 (0.37) CPB2CPB1
SCHEMBL21095371 0.73 CPB2 (0.40) CPB2CPB1
SCHEMBL15726438 0.72 CPB2 (0.38) CPB2CPB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8268894-B2 Compositions and methods for the treatment of infectious diseases THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2012-09-18 US disclosed
US-8202910-B2 Compositions and methods for treatment of infectious disease SEQUELLA, INC. (US) 2012-06-19 US disclosed
US-20110118307-A1 Compositions and methods for the treatment of infectious diseases GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2011-05-19 US disclosed
US-7842729-B2 Anti tubercular drug: compositions and methods THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2010-11-30 US disclosed
US-20090192173-A1 ANTI-TUBERCULAR DRUGS: COMPOSITIONS AND METHODS SEQUELLA, INC. 2009-07-30 US disclosed
US-7456222-B2 Anti tubercular drug: compositions and methods SEQUELLA, INC. (US) 2008-11-25 US disclosed
EP-1909780-A2 ANTI-TUBERCULAR DRUGS: COMPOSITIONS AND METHODS Sequella, Inc. (US) 2008-04-16 EP disclosed
WO-2007005896-A2 ANTI-TUBERCULAR DRUGS: COMPOSITIONS AND METHODS SEQUELLA, INC. (US) 2007-01-11 WO disclosed
US-20060148904-A1 Anti tubercular drug: compositions and methods SEQUELLA, INC. 2006-07-06 US disclosed
US-20060020041-A1 Anti tubercular drug: compositions and methods SEQUELLA, INC. 2006-01-26 US disclosed
US-6951961-B2 Methods of use and compositions for the diagnosis and treatment of infectious disease GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2005-10-04 US disclosed
EP-1513825-A2 ANTI TUBERCULAR DRUG: COMPOSITIONS AND METHODS Department of Health and Human Services (US) 2005-03-16 EP disclosed
US-20040033986-A1 Anti tubercular drug: compositions and methods PROTOPOPOVA MARINA NIKOLAEVNA (US) 2004-02-19 US disclosed
US-20040019117-A1 Anti tubercular drug: compostions and methods PROTOPOPOVA MARINA NIKOLAEVNA (US) 2004-01-29 US disclosed
US-20030236225-A1 Methods of use and compositions for the diagnosis and treatment of infectious disease GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2003-12-25 US disclosed
WO-2003096989-A2 ANTI TUBERCULAR DRUG: COMPOSITIONS AND METHODS DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2003-11-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110118307-A1 Compositions and methods for the treatment of infectious diseases TERT, C5, ELANE CPB2 1706/4885CPB1 2070/4885
US-20090192173-A1 ANTI-TUBERCULAR DRUGS: COMPOSITIONS AND METHODS RIF1, TERT, ELL CPB2 3476/4885CPB1 3926/4885
US-20030236225-A1 Methods of use and compositions for the diagnosis and treatment of infectious disease TERT, C5, DERA CPB2 1450/4885CPB1 1711/4885
US-20060148904-A1 Anti tubercular drug: compositions and methods C5, DERA, ELL CPB2 3296/4885CPB1 3424/4885
US-20060020041-A1 Anti tubercular drug: compositions and methods C5, DERA, ELL CPB2 3296/4885CPB1 3424/4885
US-20040033986-A1 Anti tubercular drug: compositions and methods C5, DERA, ELL CPB2 3296/4885CPB1 3424/4885
US-20040019117-A1 Anti tubercular drug: compostions and methods TYMS, TERT, TYMP CPB2 2970/4885CPB1 2818/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.