Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 6/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | CPB1 | P15086 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LPO | P22079 | 2/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14571377 | 0.86 | LPO (0.37) | CYP3A4CPB2CPB1CYP2C9TSHR | |
| SCHEMBL4145435 | 0.81 | GPR119 (0.36) | — | |
| SCHEMBL4619526 | 0.79 | P2RX4 (0.38) | CPB2CPB1TSHRMAPTTDP1 | |
| SCHEMBL1779971 | 0.79 | CPB2 (0.40) | CPB2CPB1 | |
| SCHEMBL9669278 | 0.77 | PDE3B (0.33) | CPB2CPB1CYP2C9TSHRCYP2C19 | |
| SCHEMBL26830769 | 0.76 | MAPT (0.36) | CYP3A4MAPTLPO | |
| SCHEMBL27397934 | 0.74 | POLB (0.33) | CYP3A4LPO | |
| SCHEMBL14825921 | 0.74 | CYP3A4 (0.33) | CYP3A4TSHRLPO | |
| SCHEMBL26242737 | 0.72 | — | — | |
| SCHEMBL24712832 | 0.71 | LPO (0.38) | CPB2CPB1MAPTLPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1152873-C | Novel diphenyl-piperidine derivate | — | 2004-06-09 | — | — | CN | disclosed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| CN-1361775-A | Novel diphenyl-piperidine derivate | ASTRAZENECA UK LTD (GB) | 2002-07-31 | — | — | CN | disclosed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | disclosed |