SCHEMBL17799755

SCHEMBL17799755

O=C(N[C@H]1CC[C@H]1c1ccc(F)cc1F)c1nccnc1Cl

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ HCRTR1 O43613 13/20 0.41
▸ FPR1 P21462 2/20 0.41
▸ FPR2 P25090 2/20 0.41
▸ MC1R Q01726 3/20 0.41
▸ TAS1R3 Q7RTX0 1/20 0.37
▸ TAS1R1 Q7RTX1 1/20 0.37
▸ TAS1R2 Q8TE23 1/20 0.37
▸ HPGD P15428 1/20 0.36
▸ HCRTR2 O43614 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17799746 0.87 MC1R (0.45) HCRTR1FPR1FPR2MC1RHCRTR2
SCHEMBL17799752 0.86 MC1R (0.42) HCRTR1FPR1FPR2MC1RTAS1R3
SCHEMBL17799730 0.85 HCRTR1 (0.53) HCRTR1MC1RHCRTR2
SCHEMBL17799632 0.84 EGFR (0.46) HCRTR1FPR1FPR2MC1RTAS1R3
SCHEMBL17799720 0.82 GRM5 (0.45) HCRTR1MC1RHCRTR2
SCHEMBL17799638 0.82 HCRTR1 (0.54) HCRTR1MC1RHCRTR2
SCHEMBL17799674 0.81 GRM5 (0.39) HCRTR1TAS1R3TAS1R1TAS1R2
SCHEMBL17799751 0.81 MC1R (0.39) HCRTR1FPR1FPR2MC1RHPGD
SCHEMBL17799646 0.81 MC1R (0.45) HCRTR1FPR1FPR2MC1R
SCHEMBL19767311 0.81 HCRTR1 (0.43) HCRTR1MC1RHCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50724-E1 4-membered ring carboxamides used as nematicides SYNGENTA CROP PROTECTION AG (CH) 2026-01-06 — — US disclosed
EP-3019476-B1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-17 — — EP disclosed
US-9867371-B2 4-membered ring carboxamides used as nematicides SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 — — US disclosed
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2016-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES TUBA3C, DDT, CYCS HCRTR1 57/4885FPR1 605/4885FPR2 395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback