SCHEMBL17799751

SCHEMBL17799751

O=C(N[C@H]1CC[C@H]1c1ccc(F)cc1F)c1ncncc1Cl

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MC1R Q01726 3/20 0.39
▸ MC4R P32245 1/20 0.37
▸ FPR1 P21462 3/20 0.37
▸ FPR2 P25090 3/20 0.37
▸ HPGD P15428 1/20 0.37
▸ HCRTR1 O43613 3/20 0.35
▸ PRCP P42785 3/20 0.34
▸ LMNA P02545 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ PKM P14618 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ AKT1 P31749 3/20 0.34
▸ RPS6KB1 P23443 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17799746 0.84 MC1R (0.45) MC1RFPR1FPR2HCRTR1LMNA
SCHEMBL16371876 0.84 P2RX7 (0.38) KMT2A
SCHEMBL17799755 0.81 HCRTR1 (0.41) MC1RFPR1FPR2HPGDHCRTR1
SCHEMBL17799730 0.78 HCRTR1 (0.53) MC1RHCRTR1
SCHEMBL16372315 0.78 AKT1 (0.39) FPR1FPR2AKT1RPS6KB1
SCHEMBL17799752 0.77 MC1R (0.42) MC1RFPR1FPR2HCRTR1
SCHEMBL17799733 0.77 HCRTR1 (0.50) MC1RHPGDHCRTR1LMNAGAA
SCHEMBL17799672 0.77 GAA (0.56) HCRTR1LMNAGAAPKMKMT2A
SCHEMBL17799646 0.76 MC1R (0.45) MC1RFPR1FPR2HCRTR1
SCHEMBL17799720 0.75 GRM5 (0.45) MC1RHCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50724-E1 4-membered ring carboxamides used as nematicides SYNGENTA CROP PROTECTION AG (CH) 2026-01-06 — — US disclosed
EP-3019476-B1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2018-01-17 — — EP disclosed
US-9867371-B2 4-membered ring carboxamides used as nematicides SYNGENTA PARTICIPATIONS AG (CH) 2018-01-16 — — US disclosed
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2016-06-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160157485-A1 4-MEMBERED RING CARBOXAMIDES USED AS NEMATICIDES TUBA3C, DDT, CYCS MC1R 2554/4885MC4R 635/4885FPR1 605/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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