Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 9/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.40 |
| ▸ | CPT1A | P50416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801043 | 0.87 | GPR119 (0.48) | FASNTLR9TLR8TLR7 | |
| SCHEMBL17801056 | 0.84 | TLR9 (0.50) | TLR9TLR8TLR7USP30LRRK2 | |
| SCHEMBL17801049 | 0.84 | CPT1A (0.52) | CPT2CPT1A | |
| SCHEMBL17801067 | 0.82 | TLR9 (0.46) | TLR9TLR8TLR7USP30CPT2 | |
| SCHEMBL17801034 | 0.77 | LRRK2 (0.43) | TLR9TLR8TLR7LRRK2 | |
| SCHEMBL17801041 | 0.76 | CPT1A (0.48) | USP30CPT2CPT1A | |
| SCHEMBL12231361 | 0.74 | USP30 (0.58) | USP30P2RY12 | |
| SCHEMBL5379740 | 0.73 | CSNK1D (0.57) | TLR9TLR8TLR7 | |
| SCHEMBL12231269 | 0.73 | KIT (0.52) | USP30 | |
| SCHEMBL17801018 | 0.73 | CSNK1D (0.50) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |