Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 2/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801024 | 0.87 | FASN (0.46) | FASNTLR8TLR7TLR9 | |
| SCHEMBL17801041 | 0.86 | CPT1A (0.48) | GPR119 | |
| SCHEMBL17801068 | 0.85 | HTT (0.47) | GPR119HTTTLR8TLR7TLR9 | |
| SCHEMBL17801083 | 0.80 | HPGDS (0.45) | HTTTLR8TLR7TLR9HPGDS | |
| SCHEMBL17801036 | 0.77 | USP30 (0.51) | HPGDS | |
| SCHEMBL17801049 | 0.77 | CPT1A (0.52) | — | |
| SCHEMBL1653375 | 0.77 | CNR1 (0.53) | HTTHPGDSCNR1 | |
| SCHEMBL10069708 | 0.77 | HPGDS (0.52) | HTTJAK2JAK3PTK2HPGDS | |
| SCHEMBL1653217 | 0.76 | HPGDS (0.64) | GPR119HTTHPGDS | |
| SCHEMBL2731621 | 0.76 | HPGDS (0.46) | HTTJAK2TLR8TLR7TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |