Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.51 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801083 | 0.81 | HPGDS (0.45) | HPGDS | |
| SCHEMBL17801033 | 0.79 | MAP3K5 (0.55) | MAP3K5CSNK1DLRRK2 | |
| SCHEMBL17801088 | 0.78 | MAP3K5 (0.52) | MAP3K5CSNK1DLRRK2 | |
| SCHEMBL17801053 | 0.78 | MAP3K5 (0.55) | MAP3K5CSNK1DLRRK2 | |
| SCHEMBL2731621 | 0.78 | HPGDS (0.46) | USP30HPGDS | |
| SCHEMBL2731625 | 0.78 | HPGDS (0.46) | USP30HPGDS | |
| SCHEMBL17801043 | 0.77 | GPR119 (0.48) | HPGDS | |
| SCHEMBL17801054 | 0.77 | CPT1A (0.55) | MAP3K5 | |
| SCHEMBL17801068 | 0.76 | HTT (0.47) | HPGDS | |
| SCHEMBL17801010 | 0.74 | HCRTR2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |