Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731625 | 0.96 | HPGDS (0.46) | HPGDSHTTTLR9TLR8TLR7 | |
| SCHEMBL2731621 | 0.96 | HPGDS (0.46) | HPGDSHTTTLR9TLR8TLR7 | |
| SCHEMBL17801068 | 0.95 | HTT (0.47) | HPGDSHTTTLR9TLR8TLR7 | |
| SCHEMBL17801067 | 0.82 | TLR9 (0.46) | TLR9TLR8TLR7 | |
| SCHEMBL15240650 | 0.82 | HSD11B1 (0.47) | TLR9TLR8TLR7 | |
| SCHEMBL2732920 | 0.81 | HPGDS (0.42) | HPGDSHTTCHEK2PIK3CDPIK3CA | |
| SCHEMBL2732410 | 0.81 | HPGDS (0.42) | HPGDSHTTCHEK2PIK3CDPIK3CA | |
| SCHEMBL15248275 | 0.81 | HPGDS (0.44) | HPGDSHTTTLR9TLR8TLR7 | |
| SCHEMBL17801036 | 0.81 | USP30 (0.51) | HPGDS | |
| SCHEMBL17801043 | 0.80 | GPR119 (0.48) | HPGDSHTTTLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |