Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 3/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801021 | 0.82 | CCNC (0.39) | CHEK2CCNCCDK8USP30CNR1 | |
| SCHEMBL17801100 | 0.81 | WNT1 (0.44) | PDPK1 | |
| SCHEMBL2731621 | 0.74 | HPGDS (0.46) | CHEK2USP30PRMT5 | |
| SCHEMBL2731625 | 0.74 | HPGDS (0.46) | CHEK2USP30PRMT5 | |
| SCHEMBL17801083 | 0.73 | HPGDS (0.45) | CHEK2PRMT5CNR1 | |
| SCHEMBL17801068 | 0.72 | HTT (0.47) | CHEK2PRMT5CNR1KMT2A | |
| SCHEMBL2732410 | 0.72 | HPGDS (0.42) | CHEK2USP30PRMT5CNR1 | |
| SCHEMBL2732920 | 0.72 | HPGDS (0.42) | CHEK2USP30PRMT5CNR1 | |
| SCHEMBL17801041 | 0.70 | CPT1A (0.48) | USP30 | |
| SCHEMBL13298102 | 0.69 | KMT2A (0.45) | CCNCCDK8USP30KMT2AUCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |