Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.50 |
| ▸ | JAK2 | O60674 | 8/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | MARK3 | P27448 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.36 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.36 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801014 | 0.74 | NISCH (0.47) | JAK2PDPK1PRKD3MAP4K4CDK2 | |
| SCHEMBL17801017 | 0.74 | PDPK1 (0.60) | PDPK1PKN2 | |
| SCHEMBL31391692 | 0.71 | CYP1A2 (0.44) | JAK2PDPK1PRKD3MAP4K4CDK2 | |
| SCHEMBL3723548 | 0.71 | DYRK1A (0.34) | JAK2PDPK1PRKD3MAP4K4CDK2 | |
| SCHEMBL29953542 | 0.70 | KIF11 (0.46) | JAK2PDPK1PRKD3MAP4K4CDK2 | |
| SCHEMBL182436 | 0.70 | KIF11 (0.46) | JAK2PDPK1PRKD3MAP4K4CDK2 | |
| SCHEMBL30855645 | 0.70 | PDPK1 (0.68) | BTKJAK2PDPK1PRKD3MAP4K4 | |
| SCHEMBL3688902 | 0.70 | DYRK1A (0.34) | JAK2PDPK1PRKD3MAP4K4CDK2 | |
| SCHEMBL9904218 | 0.70 | PIM1 (0.46) | JAK2PRKD3MAP4K4CDK2MARK3 | |
| SCHEMBL5914302 | 0.69 | BTK (0.64) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |