Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801025 | 0.88 | LRRK2 (0.50) | LRRK2ITKMKNK1 | |
| SCHEMBL5377574 | 0.82 | CSNK1D (0.46) | TRPA1MAP3K8MKNK1 | |
| SCHEMBL378124 | 0.80 | NISCH (0.58) | CHEK1 | |
| SCHEMBL17801044 | 0.79 | LRRK2 (0.52) | LRRK2TRPA1SCN5ASCN9AITK | |
| Hydrochloric Acid SCHEMBL29165675 | 0.78 | NISCH (0.56) | CHEK1 | |
| SCHEMBL17801060 | 0.78 | PDPK1 (0.60) | LRRK2ITKMAP3K8CHEK1 | |
| SCHEMBL17801064 | 0.76 | DCLK1 (0.65) | LRRK2TRPA1SCN5ASCN9AITK | |
| SCHEMBL1664137 | 0.76 | LRRK2 (0.58) | LRRK2TRPA1SCN5ASCN9AITK | |
| SCHEMBL17801014 | 0.76 | NISCH (0.47) | MAP3K8CHEK1MKNK1 | |
| SCHEMBL8253395 | 0.73 | VCP (0.47) | MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |